DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and hecw1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_017950053.1	Gene:	hecw1 / 100170498	XenbaseID:	XB-GENE-5969056	Length:	1600	Species:	Xenopus tropicalis

Alignment Length:	1477	Identity:	580/1477 - (39%)
Similarity:	753/1477 - (50%)	Gaps:	329/1477 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SDELEQAFQSALTLTNDVHVSVSEVE---------EHEPPLASRNQEVAEVEEQQQQLGACALPQ 127
            :|.:....|....:|:.:|....|:.         ....||.:.|:|.
Frog   331 TDHVSGQLQFRFEITSSIHPDDEEISVSSDTVPGTASASPLHNTNEET----------------- 378

  Fly   128 PSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTL 192
            |.|:....|..|          ...|.|.|  |..:|..       |.|..|:
Frog   379 PIESQRRASVAT----------ECSSQELP--NECISAN-------GHDKNSA------------ 412

  Fly   193 SPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTL--SMAEVDEEV 255
               ||..:....:..|..||   :.::||:|                ||:.:.|  ..||:...|
Frog   413 ---SGSRSTSQNSLHKNITG---SAMANASG----------------AELTENLDSGQAEMTLPV 455

  Fly   256 D--EEEDEEAAAVES-------LLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPP 311
            |  :...|:||.|:|       ::..|||..|.                |...|
Frog   456 DFIDSVQEQAACVDSEAKLENIVVSVAAAAAAG----------------QNENP----------- 493

  Fly   312 RAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPD---SYI 373
                            :|||.||.  ..:.:.|.....:|  ..|....||      ||   ...
Frog   494 ----------------EILDVDEE--NMLLEASKDQEKAP--EEPEGGCPL------PDGEPKLR 532

  Fly   374 NTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKAS---SSEEQA 435
            ||:..:..|.    ..|.....:.:.|:...|.:.:..|:|.|. |..:|.:.:.|   ..|||.
Frog   533 NTVKRKNRPC----SLPVSELETVIASACGEPETPRTHYIRIHN-LLHSLPSAQMSGDGDEEEQN 592

  Fly   436 SPRL-------------LLSPKRPRSP-PSG----------CSTRSASPLDISLSPEQHSPTRGR 476
            |..|             ::|.....:| ||.          .::||..||| |.||  |.|:...
Frog   593 SVDLDEESTVKETSEKDIVSETETVAPDPSSEVVIDENDDVENSRSPLPLD-STSP--HLPSCNH 654

  Fly   477 G---VGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHAR---- 534
            .   |.....::....:...||.....              |...:.....|..|..:...
Frog   655 NCLDVELLRTESESDSSARVHGDHECD--------------TCDTSCYSTSCYSTSCYSTSCYSP 705

  Fly   535 ----RHARLQAVTANSSLASGGAIPSDPPAVSSQLD-------YIYLQDGGQ--EQGQEQSD--- 583
                .|.|..:.|..||:.|  |..|:....|||.|       :..:.|..|  |..::|:|
Frog   706 SCYDSHNRFSSHTRFSSVDS--ARMSESTVFSSQDDEEDENSAFESMPDSNQSPEPERDQADGSN 768

  Fly   584 ------EVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGA------AGEP 636
                  ....::|.|...:.|   :..|..:....|...:...|.:|:......|      ..:.
Frog   769 QWSDDTSGQSVNSERTLGVLE---SPVAGPSNRTEGDCTLPNTTPSVTQLPSLRADHHHYPTIDE 830

  Fly   637 PLPPAWEARMDSHGRIFYIDHTTRTTSWQRP--GAAPSGGPAGREQHHRQQLDRRYQSIRRTITN 699
            ||||.||||:|||||:||:||..|||:||||  .|.|.|..........:||:||||:|:|||..
Frog   831 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTTAATPDGISRSGSIQQMEQLNRRYQNIQRTIAT 895

  Fly   700 E----------SRAAQL------YNLPTSANSNANSTAPAAPPPATAI--HPAILMLCRPDFYSL 746
            |          .||..:      .:.|.:......|..|......|.:  .||:..:..|:|:::
Frog   896 ERTEEDSLGRNDRAPGVGDSETDLSQPNTELRREGSLTPINSQKITLLLQSPAVKFITNPEFFTI 960

  Fly   747 LHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQS 811
            ||.|.:|..::..:..|||||::||||...|:|||:|:|||..:|.||....|||..||.|.||.
Frog   961 LHANYSAYRVFTNSTCLKHMVLKIRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQ 1025

  Fly   812 GKQFFIDHQHRRTSFMDPRLPVECPRVVRH--RQQHSQQQSSVGYYYPDLVDGNCLSATSGHINA 874
            ||.||:||..|.|:|:|||:|::..|:..|  .:||.|:..|                    .:|
Frog  1026 GKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRS--------------------YSA 1070

  Fly   875 SPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAG 939
            ..||.||        |...:|..:|..|         |.::...|..:
Frog  1071 GEASEVS--------RNRGASLLARPGH---------SLVTAVRNQHQ----------------- 1101

  Fly   940 YEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTIL 1004
            :|.||:|||:|::||||||||.|:|:|||.....:..|||||:.:|.||...||:|..|..|.||
Frog  1102 HEAVPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGTHGLEKLSCDADLVIL 1166

  Fly  1005 LSLFEQEIMGFVPIEE---------------RSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYR 1054
            |||||::||.::|::.               .|||.||.| .|...|||.|:|||||||||:|||
Frog  1167 LSLFEEDIMSYIPLQAAFHPGYSFSPRCSPGSSPQNSPGL-QRASARAPSPYRRDFEAKLRNFYR 1230

  Fly  1055 KLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFF 1119
            |||:|||||||.|:||.|||.||||..|.::|:.::|:|||.:|.:.:..||||||.||||||||
Frog  1231 KLEAKGYGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFF 1295

  Fly  1120 LLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPF 1184
            |||:|||||||||||||||||||||:||:||||:|..:|||||||:|||||:|||||||||||||
Frog  1296 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPF 1360

  Fly  1185 YKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNI 1249
            ||||||||..|||||.||.||||||||::|||| |.: |.|||.|.||:.|.|.:||||.||.||
Frog  1361 YKALLRLPCDLSDLEYLDEEFHQSLQWMKDNDI-TDI-LDLTFTVNEEVFGQVTERELKSGGANI 1423

  Fly  1250 IINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTND 1314
            .::|||||||:|:|:|||:||||.:|||:||||||||:||||||||||||||||||||||||.||
Frog  1424 QVSEKNKKEYIEKMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLND 1488

  Fly  1315 WRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCI 1379
            ||.|||||.||||.|.||.|||..:|||:||||||||||||||||:|||||:|||||.|.|||||
Frog  1489 WRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1553

  Fly  1380 EKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |||||..:|||||||||||||||||:..:|:||||:|||||:|||:|
Frog  1554 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVEETSTFGLE 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	21/28 (75%)
		HECTc	1068..1424	CDD:238033	269/355 (76%)
		HECTc	1092..1423	CDD:214523	256/330 (78%)
hecw1	XP_017950053.1	HECW_N	67..186	CDD:374632
		C2_NEDL1-like	207..343	CDD:176073	2/11 (18%)
		MSCRAMM_SdrC	<588..786	CDD:380146	44/216 (20%)
		WW	832..861	CDD:366073	21/28 (75%)
		HECW1_helix	942..1008	CDD:375862	26/65 (40%)
		WW	1014..1045	CDD:197736	18/30 (60%)
		HECTc	1268..1597	CDD:214523	256/330 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	500	1.000	Domainoid score	I349
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		oto102445
Panther	1	1.100	-	-	O	PTHR11254
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100