DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and herc5.3

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_021330683.1	Gene:	herc5.3 / 100073325	ZFINID:	ZDB-GENE-070615-14	Length:	1002	Species:	Danio rerio

Alignment Length:	928	Identity:	199/928 - (21%)
Similarity:	315/928 - (33%)	Gaps:	239/928 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   593 LPSIPERSAAAAAAAAAAAAG---AALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFY 654
            :|:| .:|.:.....:.:..|   |.|.:.||....||.|.|..|...|      :.:.|.|:.
Zfish   216 IPTI-VKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSL------KDEHHPRLV- 272

  Fly   655 IDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSAN---SN 716
                  ...|   |:..|....||  ||             |:..|..:.|:|:......   .|
Zfish   273 ------AELW---GSKVSQVTCGR--HH-------------TLVFEDSSNQIYSFGCGMQGQLGN 313

  Fly   717 ANSTAPAAPPP----------------ATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKH 765
            ......:.|.|                |...|...|....|.       ||:.......|..:..
Zfish   314 GEQVKQSVPLPVLLPTECTEFTMEKLIAGENHSFALFFKSPG-------NESEKPKSGSNGGILT 371

  Fly   766 MVMRI------RRDPPCFQRYQYN---KDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQH 821
            :..||      ..||....:.:.|   ....:|..:|.:.||:  ..::|.:::.|    :|...
Zfish   372 LNDRIIDRWVSESDPWPTIKNEINTVFSSAASLNGSFLKTSRD--EHYQTSVERCG----LDFDL 430

  Fly   822 RRTSF----MDPRLPVECPRVVRHRQQHSQQQSSVG-------YYYPDLVDGNCLSATSGHINAS 875
            .:|||    ....|..|..:||:.....|...:..|       ...|:|::|.....|    ...
Zfish   431 VKTSFAKLSTSKSLISEVVKVVQQTLLPSLNPNPTGEEALRLYLLLPELINGLKKQRT----KLI 491

  Fly   876 PASSVSGVPPLPPPRPSSSSSSSRSSHG---------HGHNCNTTSAISCALNADRSAYGAAGMA 931
            .|.:...:...|..|.......||....         |..:......||.....|:|.
Zfish   492 EALAFKILELCPAARKVLEMYWSRLPDDWFEALIKLFHKESAELIKQISRGETDDQST------- 549

  Fly   932 SAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEG-VPALERL 995
                                   ....|.||||:       |:.|:....||...:. :|.:..|
Zfish   550 -----------------------RHLKNFLEILQ-------MAYQICCSTNITNHDFIIPEVNDL 584

  Fly   996 GHDLQLTILLSLFEQEIMGF---VPIEERSPQGSPVLNSRMPQR----------APPPFRRDFEA 1047
            ...|..|      ..|::..   :||.|.       |::||...          ...||..||..
Zfish   585 LETLDAT------SAEVLWMASRLPINEE-------LHNRMKLEDYYFKTAEILVKFPFVSDFLT 636

  Fly  1048 K-----------LRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVL 1101
            |           :||....|.....|.     .|||.|..:|.|..:.:.......:.  .|.|.
Zfish   637 KKSMFILLQEQCIRSLLDLLVVHLNGN-----LLHINRESVLTDTLQYLRPFTYSFMH--PLQVA 694

  Fly  1102 WDTEEGLDYGGPSREFFFLLSREL-----------------FNPYYGLFEYSANDTYTVQVSPLS 1149
            :..|:.:|....|.|||.|:|:..                 |||::      ..|
Zfish   695 FIGEDEIDEKVISAEFFSLISKSFIEWDKKILEVHESSLVWFNPHH------TQD---------- 743

  Fly  1150 AFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRD 1214
                  |..|.:.|.:.|:||.:::.::..|....:|.||:...:|.|||.|.....:||:.:.:
Zfish   744 ------HRDFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLE 802

  Fly  1215 NDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESL 1279
            .|....|||       :.|..:...:||.|.|..|.:|:.|:::|::..:.:...:.|:.|.|..
Zfish   803 EDEEEVVDL-------QHLDFTCKGQELVPNGSQIQVNKVNRQKYVDLYVDFVFNKSVKTQFEQF 860

  Fly  1280 VRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSN 1344
            ..||.|.......::|...||:.::.|:.:.:.|:.:.:..| .|...:.::|..||.|....|.
Zfish   861 TEGFSEGCPLDAWTMFHPEELQELLHGSPQYNWNELQQSASY-EGCSASDELIKNFWTVFFELSE 924

  Fly  1345 EQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNA---LPRAHTCFNRLDLPPYPTP 1406
            |.:.:.|.|:.||..:|..|||       .|...|.:...|:.   ||.|.|||.||.||.|...
Zfish   925 ENKKKFLMFLYGTERVPAGGFS-------KRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDI 982

  Fly  1407 ELLYEKLLLAVEETNTFG 1424
            ..|.:||:.||.....||
Zfish   983 NTLRDKLIHAVNSCAVFG 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	4/28 (14%)
		HECTc	1068..1424	CDD:238033	96/375 (26%)
		HECTc	1092..1423	CDD:214523	90/350 (26%)
herc5.3	XP_021330683.1	RCC1	<74..349	CDD:332518	32/164 (20%)
herc5.3	XP_021330683.1	HECTc	665..1000	CDD:331829	96/373 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910