Protein Alignment Hecw and wwp2

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001090841.1
• Gene: wwp2 / 100038252
• XenbaseID: XB-GENE-961516
• Length: 729
• Species: Xenopus tropicalis
• Alignment Length: 1028
• Identity: 288/1028 - (28%)
• Similarity: 415/1028 - (40%)
• Gaps: 326/1028 - (31%)

  Fly   424 SNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRS---ASPLDISLSPEQHSPTRGRGVGGALQDA 485
            |:|...:|:.....:|.||.|. .|.|...:.::   ||..|::::.::|..        |::||
 Frog     3 SSGSNQTSDGFTQEKLQLSVKE-NSVPLQINLQAAHKASGDDLTIALDEHME--------AVEDA 58

  Fly   486 VPPGTPTF-HGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLA 549
              .....| :|....:::                 .||   |.:.:..:.:..:.|..|:|.::.
 Frog    59 --DSEMVFENGHYALEKI-----------------SSP---PQSASSDSSQPIKNQDNTSNITVL 101

  Fly   550 SGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGA 614
            ..|   ....|.||:||.            ...||.....|:.|||:.....:.......:...:
 Frog   102 VNG---ESSHATSSELDV------------PAQDEAFSNISSPLPSLGSELRSEDNEDTQSLQPS 151

  Fly   615 ALMEPGTGTVSG------SSG---------AGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSW 664
            ||.....|...|      |:|         .....|.|||..||.|:|:.||.:|:||.||||:|
 Frog   152 ALTPTSEGLPPGWEQRELSNGRVYYVDHNTKSTTWERPLPLGWEKRVDNRGRFYYVDHNTRTTTW 216

  Fly   665 QRPGA------APSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPA 723
            |||.|      ........:.|...|||.:|:               ||. |:||   |....|.
 Frog   217 QRPTAEYVRNYEQWQSQRNQMQGAMQQLSQRF---------------LYQ-PSSA---APDNDPL 262

  Fly   724 APPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVA 788
            .|
 Frog   263 GP--------------------------------------------------------------- 264

  Fly   789 LVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVG 853
                       ||:.||.:.| :|:.::::|..|.|.:.|||
 Frog   265 -----------LPNGWEKRQD-NGRVYYVNHNTRTTQWEDPR----------------------- 294

  Fly   854 YYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCAL 918
                          |.|.|..         |.|||
 Frog   295 --------------TQGMIQE---------PALPP------------------------------ 306

  Fly   919 NADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINI 983
                                |:|   :.|..:.|.:.
 Frog   307 --------------------GWE---MKYTSEGIRYF---------------------------- 320

  Fly   984 LRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAK 1048
                       :.|:.:.|    .|:....||   :....||.          :|..:.|.|..|
 Frog   321 -----------VDHNKRAT----TFKDPRPGF---DSGVKQGG----------SPGAYDRSFRWK 357

  Fly  1049 LRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGP 1113
            ...|.....|...   |..:|:.:.|..|.||:|::||:....||:| ||.::...||||||||.
 Frog   358 YHQFRFLCHSNAL---PSHVKISVSRQTLFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGI 418

  Fly  1114 SREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDA 1178
            :||:|||||.|:.||.|.||||:..:.|.:|::|.|:...:...:|||.||.:.:||.|...:|.
 Frog   419 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDT 483

  Fly  1179 FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELK 1243
            .||.||||.:|.....|.||||:|.||:.|:.||:||:: ...:|.|.|....|:||.|...:||
 Frog   484 GFTLPFYKRMLNKKPTLRDLESIDPEFYNSIMWIKDNNL-EECELELYFVQDMEILGEVTSHKLK 547

  Fly  1244 PGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTA 1308
            .||:||.:.|:||:|::..:..||..|||:|||.:.:.||.||:....:..||.:||||::.|..
 Frog   548 EGGENIRVTEENKEEFISLLTDWRFTRGVEEQTNAFLDGFKEVVPLEWLRYFDEKELELMLCGMQ 612

  Fly  1309 EIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTG 1373
            |||..||:.||.||. |..|.:.:.|||||::...||:|:|||||||||..:|..||..|.||.|
 Frog   613 EIDIADWQKNTIYRH-YTKNSKQVQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFVELIGSNG 676

  Fly  1374 PRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |::|||::.||...|||:||||||||||||.:.|.|.||||.|:|||..||.|
 Frog   677 PQKFCIDRVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	26/141 (18%)
		WW	638..667	CDD:459800	17/28 (61%)
		HECW1_helix	738..794	CDD:465766	0/55 (0%)
		HECTc	1068..1424	CDD:238033	171/355 (48%)
wwp2	NP_001090841.1	WW	160..189	CDD:459800	4/28 (14%)
		WW	190..219	CDD:459800	17/28 (61%)
		WW	264..294	CDD:197736	11/104 (11%)
		WW	305..335	CDD:238122	9/125 (7%)
		HECTc	375..727	CDD:238033	171/354 (48%)