Protein Alignment Hecw and smurf2

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_031750530.1
• Gene: smurf2 / 100038194
• XenbaseID: XB-GENE-481391
• Length: 752
• Species: Xenopus tropicalis
• Alignment Length: 795
• Identity: 255/795 - (32%)
• Similarity: 370/795 - (46%)
• Gaps: 208/795 - (26%)

  Fly   638 LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESR 702
            ||..||.|..:.|||.|::|.||||.|:||....|                .|.|..|
 Frog   160 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS----------------EYSSPGR------- 201

  Fly   703 AAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMV 767
                   |.|...:.|:       |.|..:.|   .|.       .|::..:|           .
 Frog   202 -------PLSCFVDENT-------PITGTNGA---TCG-------QTSDPRIA-----------E 231

  Fly   768 MRIRRDPPCFQRYQ-YNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRL 831
            .|:|.     ||:: |      :..|......:||..:|.:..|.|:.:|:..|...:::.|||:
 Frog   232 RRVRS-----QRHRNY------MSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRV 285

  Fly   832 PVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSS 896
            |                        .||.:.||                ..:.||||.....:::
 Frog   286 P------------------------RDLSNINC----------------EELGPLPPGWEIRNTA 310

  Fly   897 SSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNIL 961
            :.| .:...||..||......|:|:                                       |
 Frog   311 TGR-VYFVDHNNRTTQFTDPRLSAN---------------------------------------L 335

  Fly   962 EILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGS 1026
            .::..||.|     ||:                                        |::.||..
 Frog   336 HLVLNRQNQ-----QLK----------------------------------------EQQPPQVV 355

  Fly  1027 PVLNSRMPQRAP----PPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMS 1087
            |:  .::|....    |.::||...||:...::| |:...|..| .::.:.|..:.|:::|::|.
 Frog   356 PL--CQLPDEVECLTVPRYKRDLVHKLKILRQEL-SQQQPQAGH-CRIEVSREEIFEESYRQVMK 416

  Fly  1088 ANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFV 1152
            ...|||.: ||.:.:..||||||||.:||:.:|||.|:.|||||||:||.:|.||:|::|.||..
 Frog   417 MRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVN 480

  Fly  1153 DNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDI 1217
            .....:|.|.||::|:|:.|.:.:|..||.||||.||..|:.|.|:||:|.:.|.||.||.:|||
 Frog   481 PEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILENDI 545

  Fly  1218 GTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRG 1282
             ||| |..||||.....|.::..||||.||:|.:.|:.||||:...:.||..||::.|..:|.:|
 Frog   546 -TGV-LDHTFCVEHSAYGELIQHELKPSGKSIPVTEETKKEYVRLYVNWRFLRGIEAQFLALQKG 608

  Fly  1283 FYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQR 1347
            |.|||...|:..||.:||||:|.|..:||.|||:.||..:....|:: ::.|||:.:|.|..|:|
 Frog   609 FNEVIPQHLLKAFDEKELELIICGLGKIDVNDWKSNTRLKHCTADSN-IVKWFWKAVESFDEERR 672

  Fly  1348 LRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKW-GKPNALPRAHTCFNRLDLPPYPTPELLYE 1411
            .||||||||:|.:|.:||.||:|:.|||.|.|.:. ...|.||:|||||||:|:|||.|.|.|||
 Frog   673 ARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYETYEKLYE 737

  Fly  1412 KLLLAVEETNTFGIE 1426
            |||.|:|||..|.:|
 Frog   738 KLLTAIEETCGFAVE 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021
		WW	638..667	CDD:459800	15/28 (54%)
		HECW1_helix	738..794	CDD:465766	9/56 (16%)
		HECTc	1068..1424	CDD:238033	171/356 (48%)
smurf2	XP_031750530.1	C2_Smurf-like	13..138	CDD:176028
		PRP40	156..>237	CDD:227435	32/139 (23%)
		WW	160..189	CDD:459800	15/28 (54%)
		WW	253..284	CDD:197736	8/30 (27%)
		WW	299..331	CDD:197736	9/32 (28%)
		HECTc	397..749	CDD:238033	171/355 (48%)