Protein Alignment LysRS and MSD1

DIOPT Version :9

• Sequence 1: NP_001188571.1
• Gene: LysRS / 31904
• FlyBaseID: FBgn0027084
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_015221.1
• Gene: MSD1 / 856000
• SGDID: S000006025
• Length: 658
• Species: Saccharomyces cerevisiae
• Alignment Length: 650
• Identity: 138/650 - (21%)
• Similarity: 232/650 - (35%)
• Gaps: 214/650 - (32%)

  Fly   116 VSSSLEDF-----IAKYENSLKEGETLENVKLSVAGRVHAI--------RESGAKLIFYDLR-GE 166
            ::..|.||     |.|.....|:..|::.:|...:|:...:        :..|..|||..|| ..
Yeast    12 ITRRLADFPEANAIKKKFLFRKDTSTIKQLKGLSSGQKIVLNGWIEQKPKRVGKNLIFGLLRDSN 76

  Fly   167 GVKVQVMASAKSYKSEADFEIDTSKLRRG----DIIGVVGHPGKTKK------GELSVMPSEIKL 221
            |..:|:              :|...|.:|    |::..||.....:|      .|..|...:|.:
Yeast    77 GDIIQL--------------VDNKSLLKGFTLEDVVQAVGILSLKRKLSNEDADEYEVQLEDITV 127

  Fly   222 LSPCLHMLPHLHFGLKDKETRYRQ------------RYLDLILNNNVREKFQIRAKIISYVRQFL 274
            |:            ..:|:....|            |||.| .|...::..:.|:.|...:|...
Yeast   128 LN------------ASNKKPAQMQDFKLSAIYPPEFRYLQL-RNPKYQDFLKKRSSISKEIRNSF 179

  Fly   275 DRLGFLEIETPMMNMIAGGATAKPFV----THHNDLKMDLF-MRIAPELYHKMLVVGGLDRVYEI 334
            :...|.|:||||: ..|....|:.|:    |..:|.|...: :..:|:.|.::|:..|:::.|::
Yeast   180 NNFDFTEVETPML-FKATPEGAREFLVPTRTKRSDGKPSFYALDQSPQQYKQLLMASGVNKYYQM 243

  Fly   335 GRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITEQLVSGM---------------------- 377
            .|.||:|.:.....||||..:..||:|:..|:|.|.|:.|||:
Yeast   244 ARCFRDEDLRADRQPEFTQVDMEMAFANSEDVMKIIEKTVSGVWSKFSKKRGLLTLDSKGTLVPA 308

  Fly   378 ------VKAIRGSYK---VIYHPEGPE--GPEQEL----DFT---------PPFK---------- 408
                  |...|.:|:   ..|..:.|:  .|:.::    :|.         |.|:
Yeast   309 KKENGTVSIFRMTYEQAMTSYGIDKPDLRAPDLKIINLGEFNAFSHLNKKFPVFEVIILRSAFSN 373

  Fly   409 -------------------RVSMIKTLEEKLQV------KFPAADTFNSPE-TNQFLSQ-----L 442
                               ||.::..:|...|.      .|.|..||.:|. ..:||..     :
Yeast   374 MEEYKERWSFLTNNSNYNYRVPIVLPIENDEQANSNWFENFHAIATFENPHLITKFLKLKKGDIV 438

  Fly   443 CA-----KHQV-ECPAPRTTARLL--------------DKLVGEFIEEFCVNPTF---------- 477
            |.     .|.: |.|.|....|.|              :|.|..:|.:|   |.|
Yeast   439 CGCTREPNHSIFENPTPLGRLRQLVLQSEHGKNIYHAVNKDVASWIVDF---PLFSPVIIEDKSG 500

  Fly   478 --------------IC--EHPQIMSPLAKYHR--SIPG--LTERFELFVAKKEICNAYTELNDPV 522
                          :|  .||..|..|..|.:  ..|.  |...::|.|...|:....|.::||.
Yeast   501 KKEKLAYPEYEKDRLCSTHHPFTMVKLKDYEKLEKTPEKCLGRHYDLVVNGVELGGGSTRIHDPR 565

  Fly   523 VQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLLFP 587
            :|...||    |....|:..:|.. :...:.:.|.||..||.:|.||:...:.::.:|::|:.||
Yeast   566 LQDYIFE----DILKIDNAYELFG-HLLNAFDMGTPPHAGFAIGFDRMCAMICETESIRDVIAFP 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	137/649 (21%)
		LysRS_N	141..250	CDD:239817	26/139 (19%)
		LysRS_core	253..591	CDD:238398	103/476 (22%)
MSD1	NP_015221.1	aspS_bact	35..658	CDD:211576	131/626 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910