DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LysRS and Kars

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001124340.1	Gene:	Kars / 85305	MGIID:	1934754	Length:	624	Species:	Mus musculus

Alignment Length:	625	Identity:	414/625 - (66%)
Similarity:	487/625 - (77%)	Gaps:	37/625 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFARCALRTVQG-----SWPRCRYTGIQPLAAGFHVSAP-----QMEPSKQTKLELKRRLKAEQK 55
            |..:.|:|.|:|     ||..   .|.:.|..| |: ||     :.:|....:.|||||||||:|
Mouse     1 MLMQAAVRLVRGALRQTSWAE---WGQRELRLG-HL-APFTTLHKDQPLSDRRSELKRRLKAEKK 60

  Fly    56 AKEKAEK-----------AAAAP---AENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSPA 106
            ..||..|           .|:||   |:|..|      ||||.:.||:|:|:||.|||:||.: .
Mouse    61 LAEKEAKQKELSEKQLNQTASAPNHTADNGVG------AEEETLDPNQYYKIRSQAVQQLKVT-G 118

  Fly   107 TDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQ 171
            .|||||||||..||..||.:|.: |:.|:.|.:|.|.||||:||.|.||.|||||||||||||:|
Mouse   119 EDPYPHKFHVDISLTQFIQEYSH-LQPGDHLTDVTLKVAGRIHAKRASGGKLIFYDLRGEGVKLQ 182

  Fly   172 VMASAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFGL 236
            |||::::||||.:|....:||||||||||.|:||||||||||::|.||.||||||||||||||||
Mouse   183 VMANSRNYKSEEEFVHINNKLRRGDIIGVEGNPGKTKKGELSIIPQEITLLSPCLHMLPHLHFGL 247

  Fly   237 KDKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVT 301
            |||||||||||||||||:.||:||.:|:|||:|:|.|||.||||||||||||:|.|||.||||:|
Mouse   248 KDKETRYRQRYLDLILNDFVRQKFIVRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFIT 312

  Fly   302 HHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADI 366
            :||:|.|:|:||||||||||||||||:|||||||||||||||||||||||||||||||||||.|:
Mouse   313 YHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDL 377

  Fly   367 MDITEQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFN 431
            |:|||:::|||||:|.||||:.|||:||||...|:||||||:|:||::.||:.|.||.|....|.
Mouse   378 MEITEKMLSGMVKSITGSYKITYHPDGPEGQAYEVDFTPPFRRISMVEELEKALGVKLPETSLFE 442

  Fly   432 SPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIP 496
            :.||.:.|..:|....||||.|||||||||||||||:|..|::|||||:||||||||||:|||..
Mouse   443 TEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCISPTFICDHPQIMSPLAKWHRSKE 507

  Fly   497 GLTERFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTG 561
            ||||||||||.|||||||||||||||.||:.||:||..||||||||..:||||||:||||||||.
Mouse   508 GLTERFELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTA 572

  Fly   562 GFGMGIDRLAMFLTDSNNIKEVLLFPAMKPEDANRTAAET 601
            |:|||||||.||||||||||||||||||||||...|||.|
Mouse   573 GWGMGIDRLTMFLTDSNNIKEVLLFPAMKPEDKKETAATT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	394/564 (70%)
		LysRS_N	141..250	CDD:239817	84/108 (78%)
		LysRS_core	253..591	CDD:238398	252/337 (75%)
Kars	NP_001124340.1	PLN02502	42..604	CDD:215278	395/569 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850830
Domainoid	1	1.000	564	1.000	Domainoid score	I236
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	807	1.000	Inparanoid score	I488
Isobase	1	0.950	-	0	Normalized mean entropy	S299
OMA	1	1.010	-	-		QHG53889
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto92514
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1446
SonicParanoid	1	1.000	-	-		X1764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740