DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and KRS1

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_010322.1	Gene:	KRS1 / 851607	SGDID:	S000002444	Length:	591	Species:	Saccharomyces cerevisiae

Alignment Length:	559	Identity:	341/559 - (61%)
Similarity:	433/559 - (77%)	Gaps:	15/559 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TKLELKRRLKAEQ-KAKEKAEKAAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSP 105
            :|.|||:|:|..| :||:.|:||||.|  ..|.|||:...  .::.|::||:.||..:|||:::.
Yeast    28 SKSELKKRIKQRQVEAKKAAKKAAAQP--KPASKKKTDLF--ADLDPSQYFETRSRQIQELRKTH 88

  Fly   106 ATDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKV 170
            ..:|||||||||.|..:|:|||.: ||:||||...|:|:|||:||.||||:||.||.|.|:||:|
Yeast    89 EPNPYPHKFHVSISNPEFLAKYAH-LKKGETLPEEKVSIAGRIHAKRESGSKLKFYVLHGDGVEV 152

  Fly   171 QVMASAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTK-----KGELSVMPSEIKLLSPCLHMLP 230
            |:|:..:.|.....:|.|...|:||||:||.|:.|:|:     :||:||..|.::||:|||||||
Yeast   153 QLMSQLQDYCDPDSYEKDHDLLKRGDIVGVEGYVGRTQPKKGGEGEVSVFVSRVQLLTPCLHMLP 217

  Fly   231 HLHFGLKDKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGAT 295
            ..|||.||:|||||:||||||:|.:.|.:|..|::||.|:|:|||:..|:|:||||||:||||||
Yeast   218 ADHFGFKDQETRYRKRYLDLIMNKDARNRFITRSEIIRYIRRFLDQRKFIEVETPMMNVIAGGAT 282

  Fly   296 AKPFVTHHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAY 360
            ||||:||||||.||::|||||||:.|.||||||||||||||||||||||:||||||||||||.||
Yeast   283 AKPFITHHNDLDMDMYMRIAPELFLKQLVVGGLDRVYEIGRQFRNEGIDMTHNPEFTTCEFYQAY 347

  Fly   361 ADYADIMDITEQLVSGMVKAIRGSYKVIYHPEGPEGP--EQELDFTPPFKRVSMIKTLEEKLQVK 423
            ||..|:||:||.:.|.|||.|.|||.:.|||: |..|  |.||:|:.|:||::||:.||:...||
Yeast   348 ADVYDLMDMTELMFSEMVKEITGSYIIKYHPD-PADPAKELELNFSRPWKRINMIEELEKVFNVK 411

  Fly   424 FPAADTFNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPL 488
            ||:.|..::.||.:||.::...:::|||.|.|.||:||||||| :|:.|:|||||..|||:||||
Yeast   412 FPSGDQLHTAETGEFLKKILVDNKLECPPPLTNARMLDKLVGE-LEDTCINPTFIFGHPQMMSPL 475

  Fly   489 AKYHRSIPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSL 553
            |||.|..|||.||||:|||.|||||||||||||..||.|||:||..|..||||||||||.||.:|
Yeast   476 AKYSRDQPGLCERFEVFVATKEICNAYTELNDPFDQRARFEEQARQKDQGDDEAQLVDETFCNAL 540

  Fly   554 EYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPE 592
            |||||||||:|.|||||||||||||.|:||||||.:||:
Yeast   541 EYGLPPTGGWGCGIDRLAMFLTDSNTIREVLLFPTLKPD 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	341/559 (61%)
		LysRS_N	141..250	CDD:239817	62/113 (55%)
		LysRS_core	253..591	CDD:238398	227/339 (67%)
KRS1	NP_010322.1	PLN02502	24..579	CDD:215278	340/557 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346813
Domainoid	1	1.000	491	1.000	Domainoid score	I55
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	669	1.000	Inparanoid score	I99
Isobase	1	0.950	-	0	Normalized mean entropy	S299
OMA	1	1.010	-	-		QHG53889
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto99196
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1446
SonicParanoid	1	1.000	-	-		X1764
TreeFam	1	0.960	-	-
	16	15.740