DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and ATKRS-1

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_187777.1	Gene:	ATKRS-1 / 820343	AraportID:	AT3G11710	Length:	626	Species:	Arabidopsis thaliana

Alignment Length:	620	Identity:	340/620 - (54%)
Similarity:	427/620 - (68%)	Gaps:	52/620 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GSWPRCRYTGIQPLAAGFHVSAPQMEPSKQTKLELKRRLKAEQKAKEKAEKAAAAPAENTAGKKK 76
            |:.||.:             :|.:.|...:.|.|.|||     |.:||||||..||   .|..:|
plant    33 GAGPRSK-------------NALKKEQKMKQKEEEKRR-----KDEEKAEKAKQAP---KASSQK 76

  Fly    77 SSAAEEEEISPNEYF--KLRSAAVQELKRSPATDPYPHKFHVSSSLEDFIAKYENSLKEGETLEN 139
            :.||::||:...:|:  :|:..|.::.|   ..:||||||.||.|:..:|..| .||..|:.:||
plant    77 AVAADDEEMDATQYYENRLKYLAAEKAK---GENPYPHKFAVSMSIPKYIETY-GSLNNGDHVEN 137

  Fly   140 VKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMASA-KSYKSEADFEIDTSKLRRGDIIGVVGH 203
            .:.|:|||:.:.|.|.:||.||||.|:..||||||.| ||...||:|....|..:||||:||:|.
plant   138 AEESLAGRIMSKRSSSSKLFFYDLHGDDFKVQVMADASKSGLDEAEFLKLHSNAKRGDIVGVIGF 202

  Fly   204 PGKTKKGELSVMPSEIKLLSPCLHMLPHL---------------------HFGLKDKETRYRQRY 247
            |||||:||||:.|....|||.||||:|..                     .:.|||:|:|||||:
plant   203 PGKTKRGELSIFPRSFILLSHCLHMMPRKADNVNAKKPEIWVPGQTRNPEAYVLKDQESRYRQRH 267

  Fly   248 LDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDLKMDLFM 312
            ||:|||..||:.|:.|||||||||:|||...|||:||||||||||||.|:|||||||||.|.|:|
plant   268 LDMILNVEVRQIFRTRAKIISYVRRFLDNKNFLEVETPMMNMIAGGAAARPFVTHHNDLDMRLYM 332

  Fly   313 RIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITEQLVSGM 377
            |||||||.|.|:||||:||||||:|||||||||||||||||||||||:|||.|:|::||.::|||
plant   333 RIAPELYLKQLIVGGLERVYEIGKQFRNEGIDLTHNPEFTTCEFYMAFADYNDLMEMTEVMLSGM 397

  Fly   378 VKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPETNQFLSQL 442
            ||.:.|.||:.|:..|.:....|:||||||:|:.||..||:..::..|  ....|.|.|::|...
plant   398 VKELTGGYKIKYNANGYDKDPIEIDFTPPFRRIEMIGELEKVAKLNIP--KDLASEEANKYLIDA 460

  Fly   443 CAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTERFELFVA 507
            ||:..|:||.|:|||||||||||||:|..|||||||...|:|||||||:|||..|||||||||:.
plant   461 CARFDVKCPPPQTTARLLDKLVGEFLEPTCVNPTFIINQPEIMSPLAKWHRSKSGLTERFELFIN 525

  Fly   508 KKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDRLAM 572
            |.|:||||||||||||||:||..|..|:.:|||||..:||.||.:|||||.||||:|:|||||:|
plant   526 KHELCNAYTELNDPVVQRQRFADQLKDRQSGDDEAMALDETFCNALEYGLAPTGGWGLGIDRLSM 590

  Fly   573 FLTDSNNIKEVLLFPAMKPEDANRTAAETAPTAQQ 607
            .||||.||||||.||||:|......||: ||..::
plant   591 LLTDSLNIKEVLFFPAMRPPQEESAAAQ-APLTEE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	331/574 (58%)
		LysRS_N	141..250	CDD:239817	61/130 (47%)
		LysRS_core	253..591	CDD:238398	226/337 (67%)
ATKRS-1	NP_187777.1	PLN02502	30..611	CDD:215278	336/604 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	490	1.000	Domainoid score	I80
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	635	1.000	Inparanoid score	I191
OMA	1	1.010	-	-		QHG53889
OrthoDB	1	1.010	-	-		D837479at2759
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto4070
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840