DRSC/TRiP Functional Genomics Resources

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Protein Alignment LysRS and KARS1

DIOPT Version :9

Sequence 1:NP_001188571.1 Gene:LysRS / 31904 FlyBaseID:FBgn0027084 Length:607 Species:Drosophila melanogaster
Sequence 2:NP_001123561.1 Gene:KARS1 / 3735 HGNCID:6215 Length:625 Species:Homo sapiens


Alignment Length:617 Identity:406/617 - (65%)
Similarity:481/617 - (77%) Gaps:20/617 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFARCALRTVQGSWPRCRYT--GIQPLAAG--FHVSAPQMEPS-KQTKLELKRRLKAEQKAKEKA 60
            |..:.|:|.|:||..:..:.  |.:.|..|  ...:||..:.| ...:.|||||||||:|..||.
Human     1 MLTQAAVRLVRGSLRKTSWAEWGHRELRLGQLAPFTAPHKDKSFSDQRSELKRRLKAEKKVAEKE 65

  Fly    61 EK-----------AAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSPATDPYPHKF 114
            .|           |.||...:|.  ......|||.:.||:|:|:||.|:.:||.: ..|||||||
Human    66 AKQKELSEKQLSQATAAATNHTT--DNGVGPEEESVDPNQYYKIRSQAIHQLKVN-GEDPYPHKF 127

  Fly   115 HVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMASAKSY 179
            ||..||.|||.||.: |:.|:.|.::.|.||||:||.|.||.|||||||||||||:||||::::|
Human   128 HVDISLTDFIQKYSH-LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNY 191

  Fly   180 KSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFGLKDKETRYR 244
            |||.:|....:||||||||||.|:||||||||||::|.||.||||||||||||||||||||||||
Human   192 KSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYR 256

  Fly   245 QRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDLKMD 309
            |||||||||:.||:||.||:|||:|:|.|||.||||||||||||:|.|||.||||:|:||:|.|:
Human   257 QRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMN 321

  Fly   310 LFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITEQLV 374
            |:||||||||||||||||:|||||||||||||||||||||||||||||||||||.|:|:|||::|
Human   322 LYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMV 386

  Fly   375 SGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPETNQFL 439
            |||||.|.|||||.|||:||||...::||||||:|::|::.||:.|.:|.|..:.|.:.||.:.|
Human   387 SGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKIL 451

  Fly   440 SQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTERFEL 504
            ..:|....||||.|||||||||||||||:|..|:||||||:||||||||||:|||..||||||||
Human   452 DDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFEL 516

  Fly   505 FVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDR 569
            ||.||||||||||||||:.||:.||:||..||||||||..:||||||:||||||||.|:||||||
Human   517 FVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDR 581

  Fly   570 LAMFLTDSNNIKEVLLFPAMKPEDANRTAAET 601
            :|||||||||||||||||||||||.....|.|
Human   582 VAMFLTDSNNIKEVLLFPAMKPEDKKENVATT 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LysRSNP_001188571.1 PLN02502 42..593 CDD:215278 390/561 (70%)
LysRS_N 141..250 CDD:239817 84/108 (78%)
LysRS_core 253..591 CDD:238398 252/337 (75%)
KARS1NP_001123561.1 PLN02502 48..605 CDD:215278 390/560 (70%)
LysRS_N 153..262 CDD:239817 84/108 (78%)
LysRS_core 265..603 CDD:238398 252/337 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160482
Domainoid 1 1.000 564 1.000 Domainoid score I234
eggNOG 1 0.900 - - E1_COG1190
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4053
Inparanoid 1 1.050 801 1.000 Inparanoid score I506
Isobase 1 0.950 - 0 Normalized mean entropy S299
OMA 1 1.010 - - QHG53889
OrthoDB 1 1.010 - - D258797at33208
OrthoFinder 1 1.000 - - FOG0002656
OrthoInspector 1 1.000 - - oto88947
orthoMCL 1 0.900 - - OOG6_100559
Panther 1 1.100 - - LDO PTHR42918
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1446
SonicParanoid 1 1.000 - - X1764
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1817.750

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