DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and Kars

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001006968.1	Gene:	Kars / 292028	RGDID:	1359653	Length:	626	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	407/620 - (65%)
Similarity:	482/620 - (77%)	Gaps:	25/620 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFARCALRTVQGSWPRCRYT--GIQPLAAGFHVSAP-----QMEPSKQTKLELKRRLKAEQKAKE 58
            |..:.|:|.|:||..:..:.  |.:.|..|  ..||     :.:|....:.|||||||||:|..|
  Rat     1 MLMQAAVRLVRGSLRQTSWAEWGQRELRLG--QLAPFTTLRKDKPLSDRRSELKRRLKAEKKLAE 63

  Fly    59 KAEK------------AAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSPATDPYP 111
            |..|            .|||...:||  .....||||.:.||:|:|:||.|||:||.| ..||||
  Rat    64 KEAKQKELSEKQLNQTTAAAATNHTA--DNGVGAEEETLDPNQYYKIRSQAVQQLKVS-GEDPYP 125

  Fly   112 HKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMASA 176
            |||||..||..||.:|.: |:.|:.|.::.|.||||:||.|.||.|||||||||||||:||||::
  Rat   126 HKFHVDISLTQFIQEYSH-LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANS 189

  Fly   177 KSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFGLKDKET 241
            ::||||.:|....:||||||||||.|:||||||||||::|.|:.|||||||||||||||||||||
  Rat   190 RNYKSEEEFVHINNKLRRGDIIGVEGNPGKTKKGELSIVPREMTLLSPCLHMLPHLHFGLKDKET 254

  Fly   242 RYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDL 306
            ||||||||||||:.||:||.||:|||:|:|.|||.||||||||||||:|.|||.||||:|:||:|
  Rat   255 RYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNEL 319

  Fly   307 KMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITE 371
            .|:|:||||||||||||||||:|||||||||||||||||||||||||||||||||||.|:|:|||
  Rat   320 DMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITE 384

  Fly   372 QLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPETN 436
            :::||||::|.||||:.|||:||||...|:||||||:|:||::.||:.|.||.|....|.:.||.
  Rat   385 KMLSGMVRSITGSYKITYHPDGPEGQAYEIDFTPPFRRISMVEELEKVLGVKLPETSLFETEETR 449

  Fly   437 QFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTER 501
            :.|..:|....||||.|||||||||||||||:|..|::|||||:||||||||||:||...|||||
  Rat   450 KILDDICVARAVECPPPRTTARLLDKLVGEFLEVTCISPTFICDHPQIMSPLAKWHRCKEGLTER 514

  Fly   502 FELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMG 566
            |||||.|||||||||||||||.||:.||:||..||||||||..:||||||:||||||||.|:|||
  Rat   515 FELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMG 579

  Fly   567 IDRLAMFLTDSNNIKEVLLFPAMKPEDANRTAAET 601
            |||:.||||||||||||||||||||||...||..|
  Rat   580 IDRVTMFLTDSNNIKEVLLFPAMKPEDKKETATAT 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	390/562 (69%)
		LysRS_N	141..250	CDD:239817	83/108 (77%)
		LysRS_core	253..591	CDD:238398	250/337 (74%)
Kars	NP_001006968.1	PLN02502	43..606	CDD:215278	391/566 (69%)
Kars	NP_001006968.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..626		6/11 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354544
Domainoid	1	1.000	564	1.000	Domainoid score	I225
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	801	1.000	Inparanoid score	I472
OMA	1	1.010	-	-		QHG53889
OrthoDB	1	1.010	-	-		D258797at33208
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto96081
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1764
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770