DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and kars1

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001002386.1	Gene:	kars1 / 280647	ZFINID:	ZDB-GENE-021115-8	Length:	602	Species:	Danio rerio

Alignment Length:	569	Identity:	398/569 - (69%)
Similarity:	470/569 - (82%)	Gaps:	6/569 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KQTKLELKRRLKAEQKAKEKAEKAAAAPAE---NTAGKKKSSAAEEEEISPNEYFKLRSAAVQEL 101
            |..|.|||||:|||:||.||..|......:   |...::.:..|:||.:.||:|||:||.|:|.|
Zfish    36 KSDKSELKRRMKAEKKAAEKEAKVKEQQEQKETNDKPQQNAYGADEETLDPNQYFKIRSQAIQAL 100

  Fly   102 KRSPATDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGE 166
            | ..|.|||||||||..||.:||.:| |.|:.|:.|.:|.|:::|||||.|.|||||:|||||||
Zfish   101 K-GTAEDPYPHKFHVDLSLTEFIERY-NHLQPGDHLTDVVLNLSGRVHAKRASGAKLLFYDLRGE 163

  Fly   167 GVKVQVMASAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPH 231
            |||:||||::::|.||..|....:||||||||||.|:||||||||||::|.|:.|||||||||||
Zfish   164 GVKLQVMANSRNYTSEEAFVHINNKLRRGDIIGVRGNPGKTKKGELSIIPVEMTLLSPCLHMLPH 228

  Fly   232 LHFGLKDKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATA 296
            |||||||||||:||||||||||:.||:||..|:|||:|:|.|||:||||||||||||:|.|||.|
Zfish   229 LHFGLKDKETRFRQRYLDLILNDFVRQKFVTRSKIITYLRSFLDQLGFLEIETPMMNLIPGGAVA 293

  Fly   297 KPFVTHHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYA 361
            |||:|:||||.|:|:||||||||||||||||:|||||||||||||||||||||||||||||||||
Zfish   294 KPFITYHNDLNMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYA 358

  Fly   362 DYADIMDITEQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPA 426
            ||.|:|:|||:|:|||||.|.|:|||.|||:||||...|:||||||:|:||.:.||::|.||||.
Zfish   359 DYHDLMEITEKLLSGMVKHITGAYKVTYHPDGPEGQAYEIDFTPPFRRISMTQELEKELGVKFPP 423

  Fly   427 ADTFNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKY 491
            .||::|.|..:||..||.:.:||||.|||||||||||||:|:|..|:|||:||:||||||||||:
Zfish   424 PDTYDSDEMRKFLDDLCVQKEVECPPPRTTARLLDKLVGDFLEVKCINPTYICDHPQIMSPLAKW 488

  Fly   492 HRSIPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYG 556
            |||..||||||||||.||||||||||||||:.|||.|||||..||.|||||..:||.|||:||||
Zfish   489 HRSQKGLTERFELFVMKKEICNAYTELNDPIRQRELFEQQAKAKAEGDDEAMFIDETFCTALEYG 553

  Fly   557 LPPTGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPEDANRTAAETAPTA 605
            ||||.|:|||||||.|||||||||||||||||||||| |:.||....|:
Zfish   554 LPPTAGWGMGIDRLTMFLTDSNNIKEVLLFPAMKPED-NKPAAPAEGTS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	391/553 (71%)
		LysRS_N	141..250	CDD:239817	80/108 (74%)
		LysRS_core	253..591	CDD:238398	256/337 (76%)
kars1	NP_001002386.1	PLN02502	34..590	CDD:215278	392/555 (71%)
		LysRS_N	139..247	CDD:239817	80/107 (75%)
		LysRS_core	250..588	CDD:238398	256/337 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596863
Domainoid	1	1.000	571	1.000	Domainoid score	I215
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	805	1.000	Inparanoid score	I470
OMA	1	1.010	-	-		QHG53889
OrthoDB	1	1.010	-	-		D258797at33208
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto38629
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1446
SonicParanoid	1	1.000	-	-		X1764
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940