DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and drs1

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_588352.1	Gene:	drs1 / 2539278	PomBaseID:	SPCC1223.07c	Length:	580	Species:	Schizosaccharomyces pombe

Alignment Length:	607	Identity:	149/607 - (24%)
Similarity:	247/607 - (40%)	Gaps:	125/607 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SKQTKLELKRRLKAEQKAKEKAEKAAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKR 103
            ||:...:|::..:.|||.||:..:.|.        :||...|.|.:.|..:|..|      .|.|
pombe    33 SKKALKKLEKEREKEQKRKEREAREAE--------EKKKREANEIDYSAGKYGDL------PLNR 83

  Fly   104 SPATDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGV 168
            |.|.   |.:.:  :.:.|..||     .:|:|     :.:..||:..|..|.|:.|:.||.:..
pombe    84 STAR---PGRTY--TQISDISAK-----NDGQT-----VLLRARVYTSRLQGNKMCFFSLRQKYD 133

  Fly   169 KVQVMA-------SAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKG----ELSVMPSEIKLL 222
            .:|.:|       |.:..|......:::..|    :.|:|....:..|.    :..:..|.|.::
pombe   134 TIQALAVVNKDTISKQMVKWCGSISLESIVL----VEGIVKKSPEIIKSATVQDAEIHISSIYVI 194

  Fly   223 SPCLHMLPHL-----------------------HFGLKDKETRYRQRYLDLILNNNVREKFQIRA 264
            ||....||.|                       .|...:.:||...|.|||....| :..|.|:|
pombe   195 SPIKKNLPFLVEDAGRSEEQIRESEENAAEGDSKFVRVNLDTRLDNRVLDLRTPTN-QAIFDIQA 258

  Fly   265 KIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDLKMDLFMRIAPELYHKMLVVGGLD 329
            .|....|:||....|.||.||.|:..:....:..|...:  .|.|.|:..:|:||.:||:....:
pombe   259 GICQAFREFLLSNSFNEIHTPKMSGASSEGGSNVFKIQY--FKTDGFLSQSPQLYKQMLIAADRE 321

  Fly   330 RVYEIGRQFRNEGID-LTHNPEFTTCEFYMAYAD-YADIMDITEQLVSGMVKAIRGSYKVIYHPE 392
            ||:|||..||.|..: ..|..|||..:..||:.: |.::|:..|:|...:.|.||..|.......
pombe   322 RVFEIGPVFRAEDSNTYRHMTEFTGLDLEMAFNEHYHEVMEFIEKLFLYIFKTIREKYAKQVAVV 386

  Fly   393 GPEGPEQELDFTPP--------FK-RVSMIKTLEEKLQV----KFPAADTFN---SPETNQFLSQ 441
            ..:.|.:  ||..|        || .|.::|....:.|:    |.|..:.|:   .||.:.|
pombe   387 RQQYPSE--DFILPDADRIRFHFKDAVKLLKEAGYRKQLVPGQKVPEDEEFHYCEDPEFDDF--- 446

  Fly   442 LCAKHQVECPAPRTTARLL-DKLVGEF--IEEF--CVNPTFICEHPQIMSPLAKYHRSIPGLTER 501
                   ..|..|...::: :|...:|  |:::  .|.|.:....|:           .|..:..
pombe   447 -------STPEERALGQIVREKYHTDFYVIDKYPSSVRPFYTMPDPE-----------DPRYSNS 493

  Fly   502 FELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAG-DDEAQLVDENFCTSLEYGLPPTGGFGM 565
            ::.|:..:||.:....::||.:..||.      ||.| ..:..|  :.:..:...|.||..|.|:
pombe   494 YDFFMKGQEIMSGAQRIHDPELLVERM------KALGVSPDVGL--QQYIDAFAIGCPPHAGGGI 550

  Fly   566 GIDRLAMFLTDSNNIKEVLLFP 587
            |::|:.||..:..||:....||
pombe   551 GLERVVMFYLNLPNIRLASSFP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	147/604 (24%)
		LysRS_N	141..250	CDD:239817	28/142 (20%)
		LysRS_core	253..591	CDD:238398	93/359 (26%)
drs1	NP_588352.1	PLN02850	68..580	CDD:215456	137/564 (24%)
		AspRS_cyto_N	106..207	CDD:239815	24/109 (22%)
		AsxRS_core	231..576	CDD:238399	99/376 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910