DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and SPCC18.08

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_588387.1	Gene:	SPCC18.08 / 2539141	PomBaseID:	SPCC18.08	Length:	531	Species:	Schizosaccharomyces pombe

Alignment Length:	535	Identity:	196/535 - (36%)
Similarity:	313/535 - (58%)	Gaps:	39/535 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KKKSSAAEEEEISPNEYFKLRSAAVQELKRS---PATDPYPHKFHVSS--SLEDFIAKYENSLKE 133
            |:|::.    .:.|:.|:....|.::|.:::   .....||.....:|  ::...|.|:.|.:.:
pombe    16 KRKNTG----NLIPHVYYSEYHADIEERRKALGRLGISLYPSVTSDASTTTIPVIIEKWRNKITK 76

  Fly   134 GETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMASAKSYKSEADFE---IDTSK-LRR 194
            .| :..|:.:|.||:.:||.||:||.|:|:.....|:||:.:.|:..:|.:.:   |...| |::
pombe    77 SE-IAMVRYTVCGRISSIRYSGSKLAFFDVLYGNKKLQVVFNKKNIGTEEEMKGKFIPRLKALQK 140

  Fly   195 GDIIGVVGHPGKTKKGELSVMPSEI-KLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNNNVRE 258
            ||.|...|:.|::..||||:..:|: ||||||||.:|   ..|.:.|.|:.:|::|::.|....|
pombe   141 GDCIQCSGNVGRSGSGELSIYATELPKLLSPCLHPIP---VKLTNYEKRFEKRFVDMMSNTKSLE 202

  Fly   259 KFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDL-KMDLFMRIAPELYHKM 322
            ..:.|.:||..:|:|....||||:|||:::...|||||:||:|  :|: |:.|.:|.||||:.|.
pombe   203 LLEKRYRIIESIRKFFSERGFLEVETPILSHHFGGATARPFIT--SDIHKLPLTLRCAPELWLKQ 265

  Fly   323 LVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITEQLVSGMVKAIRGSYKV 387
            ||:||::||:|:|:.|||||||.|||||||:||.|.||.:...:..:||:|:..:...|.|:.::
pombe   266 LVIGGMNRVFELGKNFRNEGIDATHNPEFTSCEAYCAYLNLEGMKKLTEELIRFICLTINGNLQI 330

  Fly   388 IYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPETNQFLSQLCAKHQVECPA 452
                     ..|.:|....|:.:..|..|:::|.|:....|  ||....:.|..:..:.::..|.
pombe   331 ---------SGQTVDLEKGFEVIEFIPALQKELNVELSPLD--NSENCRKQLISIFKRCEIMLPK 384

  Fly   453 PRTTARLLDKLVGEFIEEF-CVNPTFICEHPQIMSPLAKYHRSIPG-----LTERFELFVAKKEI 511
            ..|.|.|||||....:.:: ..:|.|:..||::||||||....:.|     :::||||::...||
pombe   385 TCTVAHLLDKLFDSLVLKYNTSSPKFVINHPEVMSPLAKSDIKLYGAVEQRISKRFELYIGGYEI 449

  Fly   512 CNAYTELNDPVVQRERFEQQASDK-AAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDRLAMFLT 575
            ||||.|.||||.|..:|:.|..|: ..||||....|.:|..:||||||||.|:|||:|||.|.:|
pombe   450 CNAYEEENDPVAQYHKFQAQKYDRLQLGDDETPAPDSDFVHALEYGLPPTAGWGMGVDRLVMLMT 514

  Fly   576 DSNNIKEVLLFPAMK 590
            ..:.|.|:|.|.:::
pombe   515 GQSKISEILPFGSLR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	196/535 (37%)
		LysRS_N	141..250	CDD:239817	42/113 (37%)
		LysRS_core	253..591	CDD:238398	139/346 (40%)
SPCC18.08	NP_588387.1	LysU	23..531	CDD:224111	194/524 (37%)
		LysRS_N	83..194	CDD:239817	42/113 (37%)
		class_II_aaRS-like_core	197..529	CDD:294192	139/344 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870