DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LysRS and kars-1

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_495454.1	Gene:	kars-1 / 174159	WormBaseID:	WBGene00002238	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	342/566 - (60%)
Similarity:	429/566 - (75%)	Gaps:	6/566 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QTKLELKRRLKAEQKAKEKAEKAAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSP 105
            |...|.||..|..:|.:|:.||.||......|...| ...|.:...|.|||.:|...: |.:|:.
Worm    32 QNTREQKRLAKQAKKEQERLEKDAAKLNVAVADAPK-VVREADPSDPQEYFNMRVRMI-EARRAA 94

  Fly   106 ATDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKV 170
            ..:|:||||:|:.||.|||.|| ..|::.:.:|.: :|||||:|:.||||:||:|||:.|||..:
Worm    95 GDNPFPHKFNVTISLTDFITKY-TPLEKEQVVEEI-VSVAGRIHSKRESGSKLVFYDIHGEGTHI 157

  Fly   171 QVMASAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFG 235
            |:||:||.:..:.||.....:::||||:|..|...:||.||||::|:||..|:||||||||.|||
Worm   158 QIMANAKFHTGDVDFVTLHDRIKRGDIVGFTGRATRTKAGELSLIPNEILQLTPCLHMLPHSHFG 222

  Fly   236 LKDKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFV 300
            |||||.|:|:||||||||..|::.|.||:|||:::|::||.|||||:|||:||.||||||||||:
Worm   223 LKDKELRFRKRYLDLILNPRVKDNFVIRSKIITFLRRYLDNLGFLEVETPIMNQIAGGATAKPFI 287

  Fly   301 THHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYAD 365
            ||||||.|:||:|:|||||||||||||:|||||:||.||||||||||||||||||||||||||.|
Worm   288 THHNDLDMNLFLRVAPELYHKMLVVGGIDRVYEVGRLFRNEGIDLTHNPEFTTCEFYMAYADYED 352

  Fly   366 IMDITEQLVSGMVKAIRGSYKVIYHPEGPE-GPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADT 429
            ::.:||.|:|.||.:|:|:||:.|||.||. .|..|:|||||||||.|...|.|||....|...|
Worm   353 VIQLTEDLLSSMVMSIKGTYKIEYHPNGPNTEPVYEVDFTPPFKRVHMYDGLAEKLGATLPDPST 417

  Fly   430 FNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRS 494
            .::.|..:...:||..:.|:|.|||||||||||||||::|...::|||:..||||||||||:|||
Worm   418 LHTEEAREVFDKLCRDNNVDCSAPRTTARLLDKLVGEYLESTFISPTFLIGHPQIMSPLAKWHRS 482

  Fly   495 IPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPP 559
            |||||||||||...:||.|||||||||:.||:||||||.||.|||||||::||.||.:|||||||
Worm   483 IPGLTERFELFAVTREIANAYTELNDPITQRQRFEQQAKDKDAGDDEAQMIDETFCNALEYGLPP 547

  Fly   560 TGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPEDANRTAAE-TAPT 604
            |||:|||||||:|.|||:||||||||||||:|||......: .|||
Worm   548 TGGWGMGIDRLSMILTDNNNIKEVLLFPAMRPEDGTEKKTDFDAPT 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	336/551 (61%)
		LysRS_N	141..250	CDD:239817	62/108 (57%)
		LysRS_core	253..591	CDD:238398	234/338 (69%)
kars-1	NP_495454.1	MAS20	17..>97	CDD:295844	21/66 (32%)
		PLN02502	35..581	CDD:215278	336/549 (61%)
		LysRS_N	128..237	CDD:239817	62/109 (57%)
		LysRS_core	240..579	CDD:238398	234/338 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167921
Domainoid	1	1.000	523	1.000	Domainoid score	I147
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	697	1.000	Inparanoid score	I349
Isobase	1	0.950	-	0	Normalized mean entropy	S299
OMA	1	1.010	-	-		QHG53889
OrthoDB	1	1.010	-	-		D258797at33208
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto20286
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1446
SonicParanoid	1	1.000	-	-		X1764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890