DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LysRS and AgaP_AGAP007858

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_317634.3	Gene:	AgaP_AGAP007858 / 1278097	VectorBaseID:	AGAP007858	Length:	572	Species:	Anopheles gambiae

Alignment Length:	551	Identity:	391/551 - (70%)
Similarity:	456/551 - (82%)	Gaps:	4/551 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RLKAEQKAKEKAEKAAAAPA-ENTAGKKKSS--AAEEEEISPNEYFKLRSAAVQELKRSPATDPY 110
            |..|.:..:.|.|.....|. |:....||.|  .:.||.|||||||||||.||.|||:.|.|.||
Mosquito    16 RCAANEAEQGKQETKTQQPTMESKRADKKFSFTGSVEERISPNEYFKLRSVAVSELKKRPKTHPY 80

  Fly   111 PHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMAS 175
            ||||.|:.|:.|||.||::....| ||::|.:|||||||||||||.||||:||||||.|:|:|||
Mosquito    81 PHKFCVTISIGDFIGKYKDIPVAG-TLDDVSVSVAGRVHAIRESGDKLIFFDLRGEGQKLQIMAS 144

  Fly   176 AKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFGLKDKE 240
            |..|::|..|..:||:|||||||||.|.||||||||||||..:|:||:||||||||||:||||||
Mosquito   145 AAGYQNEEQFYDETSRLRRGDIIGVTGAPGKTKKGELSVMAKQIQLLAPCLHMLPHLHYGLKDKE 209

  Fly   241 TRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHND 305
            ||||||||||:|||:||..|..||:|||::|:|||..||||:|||||||||||||||||||||||
Mosquito   210 TRYRQRYLDLMLNNDVRSIFVTRARIISFIRRFLDGAGFLEVETPMMNMIAGGATAKPFVTHHND 274

  Fly   306 LKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDIT 370
            |.||||:|||||||.|||.||||||||||||||||||:|:||||||||||||||||||.|:|:||
Mosquito   275 LNMDLFLRIAPELYLKMLTVGGLDRVYEIGRQFRNEGMDVTHNPEFTTCEFYMAYADYNDLMEIT 339

  Fly   371 EQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPET 435
            |||:|.:|.::.||:||.|||||..|.|.|:||||||||:|||.|||:.|.||||.||..::||.
Mosquito   340 EQLLSSLVYSVHGSFKVKYHPEGHGGDEVEIDFTPPFKRISMIDTLEDVLSVKFPPADQLDTPEA 404

  Fly   436 NQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTE 500
            .:||.:||.:..::|..||||||||||.||||:|..|.||||||:|||||||||||||:..||||
Mosquito   405 AKFLEELCQQRNIDCQPPRTTARLLDKFVGEFLEGNCHNPTFICDHPQIMSPLAKYHRTRSGLTE 469

  Fly   501 RFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGM 565
            ||||||..|||||||||||||.|||:||:|||::||||:||||||||||||:||||||||||:|:
Mosquito   470 RFELFVMGKEICNAYTELNDPAVQRQRFKQQAAEKAAGNDEAQLVDENFCTALEYGLPPTGGWGL 534

  Fly   566 GIDRLAMFLTDSNNIKEVLLFPAMKPEDANR 596
            |||||||||||..:||||||||||||:::.|
Mosquito   535 GIDRLAMFLTDCTSIKEVLLFPAMKPDESIR 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	390/546 (71%)
		LysRS_N	141..250	CDD:239817	83/108 (77%)
		LysRS_core	253..591	CDD:238398	256/337 (76%)
AgaP_AGAP007858	XP_317634.3	PLN02502	14..562	CDD:215278	390/546 (71%)
		LysRS_N	110..219	CDD:239817	83/108 (77%)
		LysRS_core	222..560	CDD:238398	256/337 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	118	1.000	Domainoid score	I11498
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4053
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53889
OrthoDB	1	1.010	-	-		D258797at33208
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		otm49865
Panther	1	1.100	-	-	O	PTHR42918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1764
TreeFam	1	0.960	-	-
	11	10.890