DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp40 and EXOSC3

DIOPT Version :9

Sequence 1:	NP_001285565.1	Gene:	Rrp40 / 319033	FlyBaseID:	FBgn0260648	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_057126.2	Gene:	EXOSC3 / 51010	HGNCID:	17944	Length:	275	Species:	Homo sapiens

Alignment Length:	248	Identity:	100/248 - (40%)
Similarity:	157/248 - (63%)	Gaps:	26/248 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVMPGERI------------AAIE-------ELAKSKRVILGPGLRRLDDTVVASKAGPLRHKEP 52
            :|:|||.:            .|:|       ......||:.||||||..|.::.:|.|.||||||
Human    27 VVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEP 91

  Fly    53 GT------FWVDNYQRRYIPARGDLILGIVRAKAGDLYRVDIGATDTASISYLAFEAASKKNRPD 111
            |:      :|||:.|:||:|.:||.::|||.||:||:::||:|.::.||:|||:||.|:|:|||:
Human    92 GSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPN 156

  Fly   112 LIPGDLIYARVLNASADIEPELVCVNSVGKSGKLGVL-TDGFFFKCSLNLGRMLLRENCPVLAAL 175
            :..|||||.:.:.|:.|:|||:||::|.|::..:||: .||..||.:|.|.|.||..:|.::..:
Human   157 VQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEV 221

  Fly   176 TRELPYEIAVGVNGRIWLKAHSLKETVALANAISALEQSGCAEIDKICGNLGD 228
            .:..|.||..|:|||||:||.::::|:.|||.:.|.|.....:..:|...|.:
Human   222 GKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp40	NP_001285565.1	Rrp4	5..213	CDD:224022	97/231 (42%)
Rrp40	NP_001285565.1	S1_Rrp40	63..148	CDD:240216	42/84 (50%)
EXOSC3	NP_057126.2	ECR1_N	26..274	CDD:330847	100/246 (41%)
EXOSC3	NP_057126.2	S1_Rrp40	108..193	CDD:240216	42/84 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151924
Domainoid	1	1.000	149	1.000	Domainoid score	I4447
eggNOG	1	0.900	-	-		E1_COG1097
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6867
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3789
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S1604
OMA	1	1.010	-	-		QHG54235
OrthoDB	1	1.010	-	-		D1284731at2759
OrthoFinder	1	1.000	-	-		FOG0004390
OrthoInspector	1	1.000	-	-		oto88430
orthoMCL	1	0.900	-	-		OOG6_102463
Panther	1	1.100	-	-	LDO	PTHR21321
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2268
SonicParanoid	1	1.000	-	-		X3108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750