DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp40 and Exosc3

DIOPT Version :9

Sequence 1:	NP_001285565.1	Gene:	Rrp40 / 319033	FlyBaseID:	FBgn0260648	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001101406.2	Gene:	Exosc3 / 313243	RGDID:	1304739	Length:	282	Species:	Rattus norvegicus

Alignment Length:	235	Identity:	99/235 - (42%)
Similarity:	154/235 - (65%)	Gaps:	16/235 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PGERIAAIEELAKSK-RVILGPGLRRLDDTVVASKAGPLRHKEP--------------GTFWVDN 59
            |||:...:...|:.: |::.||||||..|.::.:|.|.||||||              |.:|||:
  Rat    47 PGEQPLRLNAGARPRLRIVCGPGLRRCGDRLLVTKCGRLRHKEPSGGGGGGGGGGGGGGVYWVDS 111

  Fly    60 YQRRYIPARGDLILGIVRAKAGDLYRVDIGATDTASISYLAFEAASKKNRPDLIPGDLIYARVLN 124
            .|:||:|.:||.::|||.||:||:::||:|.::.||:||||||.|:|:|||::..|||||.:.:.
  Rat   112 QQKRYVPVKGDHVIGIVVAKSGDIFKVDVGGSEPASLSYLAFEGATKRNRPNVQVGDLIYGQCVV 176

  Fly   125 ASADIEPELVCVNSVGKSGKLGVL-TDGFFFKCSLNLGRMLLRENCPVLAALTRELPYEIAVGVN 188
            |:.|:|||:||::|.|::..:||: .||..||.:|.|.|.||..:|.::..|.:..|.||..|:|
  Rat   177 ANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIVQELGKLYPLEIVFGMN 241

  Fly   189 GRIWLKAHSLKETVALANAISALEQSGCAEIDKICGNLGD 228
            ||||:||.::::|:.|||.:.|.|.....:..:|...|.:
  Rat   242 GRIWVKAKTIQQTLILANVLEACEHMTTEQRKQIFARLAE 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp40	NP_001285565.1	Rrp4	5..213	CDD:224022	96/218 (44%)
Rrp40	NP_001285565.1	S1_Rrp40	63..148	CDD:240216	43/84 (51%)
Exosc3	NP_001101406.2	S1_Rrp40	115..200	CDD:240216	43/84 (51%)
Exosc3	NP_001101406.2	KH-I_Rrp40	203..280	CDD:411954	29/76 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345456
Domainoid	1	1.000	148	1.000	Domainoid score	I4378
eggNOG	1	0.900	-	-		E1_COG1097
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6867
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4217
OMA	1	1.010	-	-		QHG54235
OrthoDB	1	1.010	-	-		D1284731at2759
OrthoFinder	1	1.000	-	-		FOG0004390
OrthoInspector	1	1.000	-	-		oto95570
orthoMCL	1	0.900	-	-		OOG6_102463
Panther	1	1.100	-	-	LDO	PTHR21321
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3108
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770