DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43755 and rrbp1a

DIOPT Version :9

Sequence 1:	NP_001259819.1	Gene:	CG43755 / 319026	FlyBaseID:	FBgn0264086	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001139027.1	Gene:	rrbp1a / 553448	ZFINID:	ZDB-GENE-030131-9795	Length:	1336	Species:	Danio rerio

Alignment Length:	775	Identity:	131/775 - (16%)
Similarity:	241/775 - (31%)	Gaps:	300/775 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 SQYPSPQAVLYDRA-------LKKSLKAASLA-------PKPPKKSNIKPKWQLQKKPPQPGAFV 168
            ||.|:|.|.:...|       ..|:.||||.|       |.||:|....|  |.||..|
Zfish   293 SQKPTPPAPVQKSAQPAPTEKSAKAQKAASTAPAQKSSPPAPPQKPASNP--QPQKGTP------ 349

  Fly   169 LNRKCLKAKLERMPNIKRQLKSNNVFSWLHCPQPADPSNPFD--------------DSAVYPA-- 217
                 |.|..:.....::.:|:.....    |.||..|:|.|              .|.:.||
Zfish   350 -----LAASQKSETPTEKSVKAQKAAP----PAPAQKSSPPDRKPSPSAPASSQNSTSGITPAPP 405

  Fly   218 -ISIEQAMDMAKPEKPPKHGLRRKHWYCPPKCGEAESKCTDYEWAKYKMDPRPDNEAFQREMANQ 281
             .::|.|     |..|...|.|:|.       .:|||       |..::.|:   .....|:..:
Zfish   406 CPTVEDA-----PPAPSPKGKRKKK-------SKAES-------ASAEVQPK---SVAPLEVVTK 448

  Fly   282 KAFKQPEPRNYDELYKSLVTCFVQDPNGKNDL---------CEALEKCCRDPKDPP--------- 328
            |......|....:...::....|:....|.|.         .:|......||.|.|
Zfish   449 KVPVMAVPPVGTQKAAAVTAVPVKAEESKQDAPPKKKSGSKKKAEPAVAADPADSPLYLPYKALL 513

  Fly   329 ------------AQGCSEFVPDGAG-------------------------GDGESAVDKD----- 351
                        ||...:.:.|.||                         .|.:.|.:::
Zfish   514 STVRSMVFSEGEAQQLIQILSDKAGIIQDTWQKATQKGDPVVLLKKQLEERDKQLAAEQEDAAAA 578

  Fly   352 KGRDKDVDIDIHVDIDKDVDIDK------DKRK-------------------------------- 378
            |||.:|::.::.|:..|...|:.      .||:
Zfish   579 KGRLRDLNKELSVEKSKVASIETRLSSQLSKREQDIIALQARMQASYQDHLAESQQLNAKLLALQ 643

  Fly   379 ---DKGKTGD---GDNENEGIGDGDGEKGGQNDKGKH------------------EKGDG----- 414
               :||....   ...||..:.|...:...|.:..::                  ||.|.
Zfish   644 DQLEKGPNAQLARLQQENSILRDALNQATSQTESKQNAELAKLRQDCVRLNKELAEKNDALQADE 708

  Fly   415 EGNKGSE-KDGGEKKPAKQNEVKENDKEKGMEKGKEKGKEKGKEKKTKEPNF-----RSSEDRPP 473
            :..|..| |....:|...|.:....:.|:.::|..|:..|:.::.::...|.     ::.:|...
Zfish   709 QLRKNLETKAASVEKQLNQMQASRANAEQALQKRLEEVSEELRQTQSNRNNLQAQLEQAQKDAAA 773

  Fly   474 VPQSKDTTHGTEESHHGDGDFGGPDGDREKGKNQPDGKSGIVDQNQGKDKDKGKGKEKGMNKKG- 537
            :.::|......|.                    :...::|.::..|.:.|.....:|:.:.::.
Zfish   774 LAEAKARVASVEV--------------------EMKERTGHLESLQSQLKQTQTEREQQLKEQND 818

  Fly   538 ----------KGKKKPKDKD-----------EDKNTKDNR-----------------SEKDCPCE 564
                      :.:|..|:|:           :.|||..|:                 .|||  .:
Zfish   819 ISETVTAELEQARKSLKEKEIAVSTLEEELTQLKNTISNQVNQVDSTTDVQHLQQSIKEKD--TQ 881

  Fly   565 ICCPPKE--------------EDTPLIKEMRRRDRERQVRDYLRQMRHRQYMECKDLKYPSPHHK 615
            |.....|              |:..:::::::..:|::.|:.|.:.:.||   ||:
Zfish   882 IAALQGELQQAKEKSSDLNKLENQEMLEQLQKSLKEKESREKLFEEQIRQ---CKE--------- 934

  Fly   616 CDPIQCNNQFC-SNPRMQTHFARVQAVRSLQQILQRRNRQGDVKISKDLDSLLARLCNSL 674
                ||:.:.. |..::.:...|:....||...||:     :|:..|:|:...::...||
Zfish   935 ----QCSTKLADSTAQLDSLHKRISEKESLMTTLQQ-----EVQQLKELNQSQSKSFESL 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43755	NP_001259819.1	III	<382..>425	CDD:164795	10/69 (14%)
rrbp1a	NP_001139027.1	Rib_recp_KP_reg	33..210	CDD:282899
		Extensin_2	179..220	CDD:252669
		MreC	<623..>683	CDD:302802	6/59 (10%)
		GAS	708..885	CDD:290562	28/198 (14%)
		Rootletin	1049..>1186	CDD:291694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NEJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900