Protein Alignment CG43755 and KTN1

DIOPT Version :10

• Sequence 1: NP_001259819.1
• Gene: CG43755 / 319026
• FlyBaseID: FBgn0264086
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001072989.1
• Gene: KTN1 / 3895
• HGNCID: 6467
• Length: 1357
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 106/619 - (17%)
• Similarity: 181/619 - (29%)
• Gaps: 250/619 - (40%)

  Fly   127 LYDRALKKSLKAASLAPKPPKKSNIKPKWQLQKKPPQPGAFVLNRKCLKAKLERMPNIKRQLKSN 191
            |||..|.|..:...|.|                           .|..|.|.|:..|.|:::::.
Human    33 LYDEVLAKQKREQKLIP---------------------------TKTDKKKAEKKKNKKKEIQNG 70

  Fly   192 NVFSWLHCPQPADPSNPFDDSAVYPAISIEQAMDMAKPEKPPKHGLRRKHWYCPPKCGEAESKCT 256
            |    ||   .:|..:...|..:..|:::|.  |...|              .|....|..|...
Human    71 N----LH---ESDSESVPRDFKLSDALAVED--DQVAP--------------VPLNVVETSSSVR 112

  Fly   257 DYEWAKYKMDPRPDNEAFQREMANQKAFKQPEPRNYDELYKSLVTCFVQDPNGKNDLCEALEKCC 321
            :.:..:.|..|..:.:..:...|::...|:.||           ....:.|.
Human   113 ERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP-----------VPVTKQPT------------- 153

  Fly   322 RDPKDPPAQGCSEFVPDGAGGDGESAVDKDKGRDKDVDIDIHVDIDKDVDIDKDKRKDKGKTGDG 386
                 ||:               |:|..|.|                     ..::|.|..:.|.
Human   154 -----PPS---------------EAAASKKK---------------------PGQKKSKNGSDDQ 177

  Fly   387 DNENEGIGDGDGEKGGQNDKGKHEKGDGEGNKGSEKDGGEKKPAKQNEVKENDKEKGMEKGKEKG 451
            |.:.|.:                                 ..|:|:.|.....:|...|.|..|.
Human   178 DKKVETL---------------------------------MVPSKRQEALPLHQETKQESGSGKK 209

  Fly   452 KEKGKEKKTK-----EPNFRS--------SEDRPPVPQSK--------DTTHGTEESHHGDGDFG 495
            |...|::||:     ||...:        :.|..||...:        |...|.::|
Human   210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKS-------- 266

  Fly   496 GPDGDREKGKNQPDGKSGIVDQNQGKD----------------------KDKGKGKEKGMNKKGK 538
                ..:|.|.:.|.::..|   :.||                      |:|....:..:.|..|
Human   267 ----GTKKLKTETDKENAEV---KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSK 324

  Fly   539 G-------KKKPKD------KDEDKNTKDNRSE--KDCPCEICCPPKEEDTPLIKEMRRR----D 584
            |       :.:.||      |::...|||...:  ::...|     ||....:|..|:.|    :
Human   325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE-----KERSNVVITRMKDRIGTLE 384

  Fly   585 RERQVRDYLRQMRHRQYMECKDLKYPSPHHKCDPIQCNNQFCSNPRMQTHFARVQAVRS-LQQIL 648
            :|..|   .:...|..|.|.:.::.     |...::        .:|:...|.::.... |:..:
Human   385 KEHNV---FQNKIHVSYQETQQMQM-----KFQQVR--------EQMEAEIAHLKQENGILRDAV 433

  Fly   649 QRRNRQGDVKISKDLDSL---LARLCNSLTISDG 679
            .....|.:.|.|.:|:.|   .|||.|.||...|
Human   434 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTG 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43755	NP_001259819.1	III	<382..>425	CDD:164795	3/42 (7%)
KTN1	NP_001072989.1	Rib_recp_KP_reg	29..160	CDD:461548	35/220 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..81		11/66 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..218		29/212 (14%)
		EnvC	316..>532	CDD:443969	36/173 (21%)
		SMC_prok_B	448..1270	CDD:274008	9/20 (45%)
		Smc	<1190..>1357	CDD:440809