DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31915 and colgalt2a

DIOPT Version :9

Sequence 1:	NP_723087.1	Gene:	CG31915 / 319025	FlyBaseID:	FBgn0051915	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_017208065.2	Gene:	colgalt2a / 558068	ZFINID:	ZDB-GENE-070705-32	Length:	599	Species:	Danio rerio

Alignment Length:	555	Identity:	249/555 - (44%)
Similarity:	342/555 - (61%)	Gaps:	36/555 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SPTVLIALLVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWLDNSGDLYHSV 93
            :|.|.||:|.||..|.||.||..:|:.||||:||:||...||:.|::..:||:|:....||||||
Zfish    41 NPKVAIAILARNSEHSLPYFLGCIERLDYPKDRISIWAATDHNTDNTTGMLREWIAGVEDLYHSV 105

  Fly    94 S-YEFKPEEQSFVNGTSPYEWPASRFKHLIALKEEAFQYGRDIWADYVFFLDADVLLTSKDSLKV 157
            . :..:.|:.|:|:...|..||.:||.|::.|::.|.:..|..|||||.|.|:|.|||:...|..
Zfish   106 QLHTMEQEKSSYVDELGPKHWPETRFTHVMKLRQAALKSARAQWADYVLFTDSDNLLTNTQVLNQ 170

  Fly   158 LTRLQLPIVAPMLISESLYSNFWCGMTEDYYYRRTDEYKEIYHVKKQGSFPVPMVHTAVLVNMNH 222
            |......:|||||.|.:||||||||||...||:||..|..|...|:.|..||||:|:.:|:::..
Zfish   171 LISENRTLVAPMLDSRTLYSNFWCGMTSQGYYKRTPHYVPIRTWKRTGCHPVPMIHSTMLIDLRR 235

  Fly   223 RAVRNLTFDRNKLVELQKSRQQEPL---YDGPADDIIVFAISANSSGIPLHICNDITFGYILQPL 284
            ||...|.|              .|:   |....|||:.||.||..:|:.:.|||...:||:.|||
Zfish   236 RASELLAF--------------YPVHHHYLWALDDIMAFAFSARQTGVQMFICNREHYGYLPQPL 286

  Fly   285 EPGDTLDHDVQQLVNLKSIMVNELGAVPPLLDY------YKHLEKKPEKSKLSLDRIFMINLKRR 343
            :...||:.:|:..    |..|.|     .|:|:      |.|:..|| |..::.:::::||||||
Zfish   287 QMKQTLEEEVESF----SHTVTE-----ALVDFKMETSQYLHIVSKP-KDTMAFNQVYLINLKRR 341

  Fly   344 PERREKMERLFDEIGIEAEHFPAVDGKELSTERLLEMGVRFLPGYEDPYHHRAMTMGEIGCFLSH 408
            .:||::|.|..:.:||:.....|||||.:::.:|..:|:..|||::|||..|.:|.|||||||||
Zfish   342 EDRRDRMLRSLEVLGIDVTLTDAVDGKAMNSTQLRTLGIEMLPGFKDPYSDRVLTKGEIGCFLSH 406

  Fly   409 YNIWVMMVRKQLKEVLILEDDIRFEPYFRQNAVRILNQA-RNAAQYDLIYFGRKRLK-EESEPAV 471
            ||||..:|..|.::||:||||:|||..|:.....|:... |:..|:||||.|||||: :..|..|
Zfish   407 YNIWKKVVELQQQQVLVLEDDVRFETNFKSRLNTIMEDVKRSGLQWDLIYVGRKRLQIKHPERWV 471

  Fly   472 ENADNLVHAGYSYWTLGYVISLQGALKLLAAKPLDKLIPVDEFLPLMFDRHPNKTWTEAFPKRNL 536
            |...|||...||||||||.:|||||..||.|:||.|::|||||||:||::||.|.:...|..|||
Zfish   472 EGVKNLVSPDYSYWTLGYALSLQGAKILLEAQPLSKMLPVDEFLPVMFNKHPKKEYMSHFQLRNL 536

  Fly   537 VAFSASPLLLYPIYYTGESGYISDTEDSQQISVET 571
            .|||..||||:|.:||||:||.||||.|.....||
Zfish   537 KAFSVQPLLLFPTHYTGEAGYFSDTETSSIWDDET 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31915	NP_723087.1	Glyco_tranf_GTA_type	32..>146	CDD:299700	51/114 (45%)
CG31915	NP_723087.1	Glyco_transf_25	334..515	CDD:133474	93/182 (51%)
colgalt2a	XP_017208065.2	Glyco_tranf_GTA_type	51..164	CDD:325014	50/112 (45%)
colgalt2a	XP_017208065.2	Glyco_transf_25	332..515	CDD:133474	93/182 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595791
Domainoid	1	1.000	197	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG4179
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110965
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1505
OMA	1	1.010	-	-		QHG48029
OrthoDB	1	1.010	-	-		D327409at33208
OrthoFinder	1	1.000	-	-		FOG0001447
OrthoInspector	1	1.000	-	-		otm24315
orthoMCL	1	0.900	-	-		OOG6_101871
Panther	1	1.100	-	-	O	PTHR10730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3744
SonicParanoid	1	1.000	-	-		X909
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800