DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31915 and D2045.9

DIOPT Version :9

Sequence 1:	NP_723087.1	Gene:	CG31915 / 319025	FlyBaseID:	FBgn0051915	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001021233.1	Gene:	D2045.9 / 3565069	WormBaseID:	WBGene00008426	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	180/566 - (31%)
Similarity:	285/566 - (50%)	Gaps:	73/566 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DEEDYQE-SPTVLIALLVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWLDN 85
            ||.|.:. .|.|.|.:.:...||.:|.||.:||..||||:||.:.:......|.:|..::.|||:
Worm    27 DEGDVRHIYPPVYIGVGLGEHAHAIPYFLGWLENLDYPKDRIKVEIFILSKEDATIHQVKWWLDS 91

  Fly    86 SGDLYHSVSYEFKPEEQSFVNGTSPYEWPASRFKHLIALKEEAFQYGRDIWADYVFFLDADVLLT 150
            :...:.||    |..|:|       ..|..|..::....|.|.           ...:..|.:.|
Worm    92 TKQYFKSV----KIIEES-------ENWLESGLRNARLQKVER-----------CLLISGDTVPT 134

  Fly   151 SKDSLKVLTRLQLPI-VAPMLISESLYSNFWCGMTEDYYYRRTDEYKEIY----HVKKQ-GSFPV 209
            ..:.::.|...:..: |:|:..|....||.             ||..|..    :|::: .||.:
Worm   135 EMNLIQFLFNEKTHVAVSPLFQSIDGSSNI-------------DEPSETLINQNNVREEILSFSL 186

  Fly   210 PMVHTAVLVNMNHRAVRNLTFDRNKLVELQKSRQQEPLYDGPADDIIVFAISANSSGIPLHICND 274
            |:......::.::     ||||::.|          |.|:|..|...||.:||.:.||.|...|.
Worm   187 PLAIDLTTIDSSY-----LTFDKDNL----------PNYEGADDPSEVFVVSAKNMGIQLWADNQ 236

  Fly   275 ITFGYILQPLEPGDTLDHDVQQLVNLKSIMVNELGAVPPLLDYYKHLEK--KPEKSKLSLDRIFM 337
            :.:|:.:.|       :.|:::..:.....:.:..|....|.:.....:  :.|.:|..:|:|::
Worm   237 VNYGFFVNP-------EKDIEERRSTIRYQIADFLADERPLPFVSRSVRPWQSEATKQGVDKIYL 294

  Fly   338 INLKRRPERREKMERLFDEIGIEAEHFPAVDGKELS--TERLLEMGVRFLPGYEDPYHHRAMTMG 400
            :|||||.||..:|:::||.:|||.....|.||::|.  .|.|  ...:.|.||.||...|.|..|
Worm   295 VNLKRRQERLNRMQKIFDILGIEYSLLEATDGQKLDELPEEL--KNYQILEGYLDPISKRPMKNG 357

  Fly   401 EIGCFLSHYNIWVMMVRKQLKEVLILEDDIRFEPYFRQNAVRILNQARNAAQ--YDLIYFGRKRL 463
            |||||||||.:|..:|:...::|::.|||:||. :.....:|.:.|..:|:.  :||||.|||:.
Worm   358 EIGCFLSHYRVWQDVVQHNYEKVIVFEDDLRFS-HDGLTRIREVLQDLDASHKPWDLIYLGRKKQ 421

  Fly   464 KEESEPAVENADNLVHAGYSYWTLGYVISLQGALKLLAAKPLDKLIPVDEFLPLMFDRHPNKTWT 528
            .|..|..:....:|....||||||||::||.||.|||...||.|::||||:||:||::||||.|:
Worm   422 SENEELWISQHRHLSSVEYSYWTLGYMLSLNGARKLLRPNPLKKMVPVDEYLPIMFNKHPNKDWS 486

  Fly   529 EAFPKRNLVAFSASPLLLYPIYYTGESGYISDTEDSQQISVETSEE 574
            ..|...::.||:..||:::|..||.|.||:||||||..::.:...|
Worm   487 LHFEPLDVEAFTLYPLVVFPQKYTNEPGYVSDTEDSVIVTPKPKSE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31915	NP_723087.1	Glyco_tranf_GTA_type	32..>146	CDD:299700	29/113 (26%)
CG31915	NP_723087.1	Glyco_transf_25	334..515	CDD:133474	80/184 (43%)
D2045.9	NP_001021233.1	Glyco_transf_25	291..473	CDD:133474	80/184 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167144
Domainoid	1	1.000	149	1.000	Domainoid score	I2729
eggNOG	1	0.900	-	-		E1_KOG4179
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110965
Inparanoid	1	1.050	258	1.000	Inparanoid score	I1935
Isobase	1	0.950	-	1	Normalized mean entropy	S4597
OMA	1	1.010	-	-		QHG48029
OrthoDB	1	1.010	-	-		D327409at33208
OrthoFinder	1	1.000	-	-		FOG0001447
OrthoInspector	1	1.000	-	-		oto17879
orthoMCL	1	0.900	-	-		OOG6_101871
Panther	1	1.100	-	-	LDO	PTHR10730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3744
SonicParanoid	1	1.000	-	-		X909
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750