Protein Alignment CG31915 and COLGALT2

DIOPT Version :9

• Sequence 1: NP_723087.1
• Gene: CG31915 / 319025
• FlyBaseID: FBgn0051915
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_055916.1
• Gene: COLGALT2 / 23127
• HGNCID: 16790
• Length: 626
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 260/625 - (41%)
• Similarity: 379/625 - (60%)
• Gaps: 55/625 - (8%)

  Fly     9 LLLACILV---C----ISGQDEEDYQE-----------SPTVLIALLVRNKAHILPMFLSYLEQQ 55
            |||:..|:   |    ::.:|.||..|           |||||:|:|.||.||.||.||..||:.
Human    14 LLLSSALLREGCRARFVAERDSEDDGEEPVVFPESPLQSPTVLVAVLARNAAHTLPHFLGCLERL 78

  Fly    56 DYPKERIAIWLRCDHSNDDSIELLRQWLDNSGDLYHSVSYEFKPEEQSFVNGTSPYEWPASRFKH 120
            ||||.|:|||...||:.|::.|:.|:||.|...|||.|.:....|.:|:.:...|..||.|||.|
Human    79 DYPKSRMAIWAATDHNVDNTTEIFREWLKNVQRLYHYVEWRPMDEPESYPDEIGPKHWPTSRFAH 143

  Fly   121 LIALKEEAFQYGRDIWADYVFFLDADVLLTSKDSLKVLTRLQLPIVAPMLISESLYSNFWCGMTE 185
            ::.|::.|.:..|:.|:||:.|:|.|..||:..:|.:|......||||||.|..||||||||:|.
Human   144 VMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLLIAENKTIVAPMLESRGLYSNFWCGITP 208

  Fly   186 DYYYRRTDEYKEIYHVKKQGSFPVPMVHTAVLVNMNHRAVRNLTFDRNKLVELQKSRQQEPLYDG 250
            ..:|:||.:|.:|...|:.|.|||||||:..|:::...|...|||         ....|:  |..
Human   209 KGFYKRTPDYVQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLTF---------YPPHQD--YTW 262

  Fly   251 PADDIIVFAISANSSGIPLHICNDITFGYILQPLEPGDTLDHDVQQLVNLK-SIMVNELGAVPPL 314
            ..|||||||.|:..:||.:::||...:||:..||:|..||..|::.|:::: ..|::.    ||:
Human   263 TFDDIIVFAFSSRQAGIQMYLCNREHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDR----PPM 323

  Fly   315 --LDYYKHLEKKPEKSKLSLDRIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERL 377
              ..|...:.|.|:  |:..|.|||||||||.:||::|.|...|..||.:...|||||.|:|.:|
Human   324 EPSQYVSVVPKYPD--KMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQL 386

  Fly   378 LEMGVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWVMMVRKQLKEVLILEDDIRFEPYFRQNAVR 442
            ..:.:..||||.|||..|.:|.||||||||||::|..::.::|::.|::|||:|||..|::..::
Human   387 KALNIEMLPGYRDPYSSRPLTRGEIGCFLSHYSVWKEVIDRELEKTLVIEDDVRFEHQFKKKLMK 451

  Fly   443 ILNQARNA-AQYDLIYFGRKRLK-EESEPAVENADNLVHAGYSYWTLGYVISLQGALKLLAAKPL 505
            :::....| ..::|||.||||:: :|.|.||.|..|||.|.||||||||||||:||.||:.|.|.
Human   452 LMDNIDQAQLDWELIYIGRKRMQVKEPEKAVPNVANLVEADYSYWTLGYVISLEGAQKLVGANPF 516

  Fly   506 DKLIPVDEFLPLMFDRHPNKTWTEAFPKRNLVAFSASPLLLYPIYYTGESGYISDTE-----DSQ 565
            .|::|||||||:|:::||...:.|.:..|:|.||||.|||:||.:|||:.||:||||     |::
Human   517 GKMLPVDEFLPVMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNE 581

  Fly   566 QISVETSEEGEARLKSDREQVFDHEQEFKLNPELKLGESL 605
            .::.:.          ||...:...::.::....|..|:|
Human   582 TVATDW----------DRTHAWKSRKQSRIYSNAKNTEAL 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31915	NP_723087.1	Glyco_tranf_GTA_type	32..>146	CDD:299700	51/113 (45%)
		Glyco_transf_25	334..515	CDD:133474	93/182 (51%)
COLGALT2	NP_055916.1	Glyco_tranf_2_4	62..175	CDD:316244	50/112 (45%)
		Glyco_transf_25	341..526	CDD:321436	94/184 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	604..626		3/8 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	623..626

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159592
Domainoid	1	1.000	197	1.000	Domainoid score	I3095
eggNOG	1	0.900	-	-		E1_KOG4179
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1463
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48029
OrthoDB	1	1.010	-	-		D327409at33208
OrthoFinder	1	1.000	-	-		FOG0001447
OrthoInspector	1	1.000	-	-		otm41364
orthoMCL	1	0.900	-	-		OOG6_101871
Panther	1	1.100	-	-	LDO	PTHR10730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3744
SonicParanoid	1	1.000	-	-		X909
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800