DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and VPS27

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_014403.3	Gene:	VPS27 / 855739	SGDID:	S000005289	Length:	622	Species:	Saccharomyces cerevisiae

Alignment Length:	493	Identity:	94/493 - (19%)
Similarity:	172/493 - (34%)	Gaps:	136/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 LC--EVQETMQLLNQMLDTYDPANQDVSETLHELYKSCKKHKPIFQHLPQLLDDSDAQLVADTLD 268
            :|  |..:||:.:....|:.:..::.|...|:|||.:.|             :||....||...|
Yeast    88 ICSREFMDTMEHVILREDSNEELSELVKTILYELYVAFK-------------NDSQLNYVAKVYD 139

  Fly   269 ANCALLATMQRYKLL---VPSPTRSTAAALTTSAPTVASSVKSTA---SSTTATTSSNNAQLLNE 327
                        ||:   :..|.:.|    .:::||.....|:.|   .|......|....|||.
Yeast   140 ------------KLISRGIKFPEKLT----LSNSPTAMFDSKTPADWIDSDACMICSKKFSLLNR 188

  Fly   328 LLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLS-----DIFSSALAESEAKQQSQPFQN--- 384
                      .....:.........:|.|.||.||.     .:..|...:.:.|:.....::
Yeast   189 ----------KHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYDLKRHDDSKKSKKH 243

  Fly   385 ----------ATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDMLSEELFQQILPTQ 439
                      :|...|.::|.:........:.|..|:..:      :|.::..:|...|:|...:
Yeast   244 RHKRKKDRDYSTPEDEEELIRKAIELSLKESRNSASSEPI------VPVVESKNEVKRQEIEEEE 302

  Fly   440 DRMPSFK-------RDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVDSIDDV 497
            |  |..|       |:.|:..|....::......|::|:....|              :.|:|
Yeast   303 D--PDLKAAIQESLREAEEAKLRSERQKASRQMQPQQPSPQPQP--------------IHSVD-- 349

  Fly   498 PLLSDDVEKKDEAVVAPVTVVPPAKPLSEI--NVELDNIQATGEQRIVLDDDDMQLSLNFTSDR- 559
              |||: ||....:.|.:.....::||:||  :.:|.|:    .||:......:..:||..:.:
Yeast   350 --LSDE-EKDSIYMFASLVEKMKSRPLNEILEDSKLQNL----AQRVFASKARLNYALNDKAQKY 407

  Fly   560 -----PGHRVSVIV----------ISAQNKSRQ------PVRDFQF-EASVKKPCKVRLLTPTDS 602
                 ...::|.|:          :.:.|.|:|      |...:.: ..:|:.|.: ...||...
Yeast   408 NTLIEMNGKISEIMNIYDRLLEQQLQSINLSQQYTLPQVPSDPYNYLTENVQNPAE-SYQTPPLQ 471

  Fly   603 QMPPH--KPFRPATPINQVMLLLNPTG-----KAVDVT 633
            |:..|  ||.:..:....|....:||.     |.:|||
Yeast   472 QLSSHQYKPQQDVSRQQSVKANSSPTTNIDHLKTIDVT 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624
		GAT	210..284	CDD:281166	16/76 (21%)
		Alpha_adaptinC2	543..644	CDD:197886	23/121 (19%)
VPS27	NP_014403.3	VHS_Vps27	7..149	CDD:340776	18/85 (21%)
		FYVE_like_SF	169..226	CDD:333710	12/66 (18%)
		GAT_Vps27	349..432	CDD:410590	19/91 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930