DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and GGA1

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_010645.1	Gene:	GGA1 / 851960	SGDID:	S000002766	Length:	557	Species:	Saccharomyces cerevisiae

Alignment Length:	539	Identity:	124/539 - (23%)
Similarity:	223/539 - (41%)	Gaps:	103/539 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TTDESIMEEMLERATNPAQKIDELGVQM-FCIVVKSNAQLVHKAQEMIVAKVRSTNVTE-ATRAI 64
            :|:.|::.: ::||........:||:.: ....:.|......:...:.:.|:.:...|: |..|:
Yeast    17 STESSLLRK-IQRACRSTLPEPDLGLNLDVADYINSKQGATPREAVLAIEKLVNNGDTQAAVFAL 80

  Fly    65 SLLEECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETP----HEVKQRIMECLLLWTTEFPQ 125
            |||:..:..||.....:.|:..|||:|::      :..|.|    .:|:|.|:|.:..|.....:
Yeast    81 SLLDVLVKNCGYSIHLQISRKEFLNDLVK------RFPEQPPLRYSKVQQMILEAIEEWYQTICK 139

  Fly   126 R-------QKIRDAYDMLRKEGDI--EHGTTEAAVAKRESVLGTIDE----------AMFAKLIK 171
            .       |.|.|.:.:|:.:|..  :.|:...||.:....|.|..|          |...:|::
Yeast   140 HASYKDDLQYINDMHKLLKYKGYTFPKVGSENLAVLRPNDQLRTPSELQEEQERAQAAKLEELLR 204

  Fly   172 SNNPENFKRANLLLQYRMA----------QEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDPA 226
            |..|::.|.||.|::. ||          ::|..|:        |.:::....|.|:||.:.|..
Yeast   205 SGKPDDLKEANKLMKI-MAGFKDDTKVAVKQAINNE--------LNKLKRKADLFNEMLTSADEP 260

  Fly   227 NQDVSETLHELYKSCKKHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYK---------L 282
            :.: :|.:.|||...|..:|.|:.|.:...|.|| ||::....|..::..::|||         |
Yeast   261 DLE-NEAIQELYGDLKSAQPKFKKLIEEERDDDA-LVSNLSKFNDLVIQLLKRYKSIKGMKEEEL 323

  Fly   283 LVPSPTRSTAAALTTSAPTVASSVKSTASSTTATTSSNNAQLLNELLGDLLIDGSNKAATTATTS 347
            .||. |...|..|.    .:.....:||::.:.|:.|.:.|..::||||.     ||    .:.|
Yeast   324 NVPD-TNEPAKELN----LIDFDDDTTANTPSVTSPSKSLQPFDDLLGDF-----NK----VSLS 374

  Fly   348 LPNAAASGSNPLADLSDIFSSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANG--NGGS 410
            .|.:.......:..|.|..|.:.........|||.::.|.|      |..:.:..|.||  |..|
Yeast   375 SPKSPQENDTVVDILGDAHSKSSGIDLLDFDSQPGESKTAL------SAYSNSIVLPNGLLNSSS 433

  Fly   411 ASKVPETIRKMPQIDMLSEELFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTAND 475
            .||         :|...|:   :.||...|.:    |...::|...:.:.|:.|   .....::|
Yeast   434 NSK---------EITAQSQ---RHILNQSDHL----RIDYELTRESMTKLRLVI---FYSNISSD 479

  Fly   476 PASDSAPAIATATATVDSI 494
            |.::.|..:|:...|..|:
Yeast   480 PITNFALLVASPKGTTLSL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	31/151 (21%)
		GAT	210..284	CDD:281166	23/82 (28%)
		Alpha_adaptinC2	543..644	CDD:197886
GGA1	NP_010645.1	VHS_GGA_fungi	22..160	CDD:340795	30/144 (21%)
		GGA_N-GAT	195..222	CDD:408115	8/27 (30%)
		GAT_GGA_fungi	233..320	CDD:410583	25/96 (26%)
		Alpha_adaptinC2	443..555	CDD:397151	13/66 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51934
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950