DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and gga1

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001004000.2	Gene:	gga1 / 798361	ZFINID:	ZDB-GENE-040822-13	Length:	635	Species:	Danio rerio

Alignment Length:	702	Identity:	179/702 - (25%)
Similarity:	316/702 - (45%)	Gaps:	154/702 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DESIMEEMLERATNPA-QKIDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLL 67
            ||..:|..:.:||||. ::.|...:|:||..:.:..:....|..::..|::|....||.:|:.:|
Zfish     6 DEQSLESRINKATNPLNRETDWESIQLFCDQLSNEPEGPQLATRLLAHKIQSPQEWEAIQALMVL 70

  Fly    68 EECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDA 132
            |.|:..||..|.:|..|||||||||::||.||.|:..|..||::::|.:..||...|:..||.||
Zfish    71 ETCVKNCGKRFHNEVGKFRFLNELIKVVSPKYLGSRAPEPVKKKVLEMMYSWTVSLPEETKISDA 135

  Fly   133 YDMLRKEGDIEHG--------------TTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANL 183
            |.||:|:|.|:..              ..:.|:.:.|.     ...|.::|:.|::||:.:.||.
Zfish   136 YQMLKKQGIIKQDPDLPDDKPCPPPPPRPKNAIFEDEE-----KSKMLSRLLNSSHPEDLRAANK 195

  Fly   184 LLQYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTY--DPANQDVSETLHELYKSCKKHKP 246
            |::..:.::.:|.:.:::....:.||:|::.||.|:|..|  |.::|...|.:.:||:.|:|.:|
Zfish   196 LIKEMVQEDQKRMEKVSKRVNAIQEVKESVGLLTQLLGDYSKDSSSQSNEELIKDLYQRCEKMRP 260

  Fly   247 IFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTAS 311
            ....|....:|:| :.:|:.|.||.:|...:..|:.||.                 ...|...||
Zfish   261 TLFRLASDTEDND-EALAEILQANDSLTQVINLYRQLVR-----------------GEEVNGEAS 307

  Fly   312 STTATTSSNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAESEAK 376
            |:.....|:||                                    |.||:.:.:|..|:|.::
Zfish   308 SSATHPGSSNA------------------------------------LLDLTGLDTSPSAQSFSE 336

  Fly   377 QQSQPFQNATTLLEPQVISQGTT--TEALANGNGG-----------------------------S 410
            ..||..:...:||:.:::|.|.|  ...|.:...|                             |
Zfish   337 FPSQTQELGISLLDDELMSLGLTEVNSNLTSSQSGDAMGWNTFQSSETEDTPVMPEPAVLLPVTS 401

  Fly   411 ASKVPETI-----RKMPQIDMLSEELFQQILPTQ------DRMPSFKRDPEKITLNDLARERMHI 464
            |:|.|..:     :.:.::|:|.:.|.||.||.:      |::.|    ..|.||.||     .|
Zfish   402 ATKTPVPVPVTSTKSLDELDLLGKTLLQQSLPPEGLQVKWDKLQS----QSKPTLRDL-----QI 457

  Fly   465 KAPEEPTTANDPASDSAPAIATATATVDSIDDVPLLSDDVEKKDEAVVAPVTV-VPPAKPLSEIN 528
            |      :.|:.|:..:|.::.      |.:...||:..:..:|:..:..||| :...||.|.:.
Zfish   458 K------SGNNAATSPSPVLSF------SSEPGSLLNSQLTPQDDVSLVKVTVPLESIKPSSMLP 510

  Fly   529 VELDNIQATGEQRIVLDDDDMQLSLNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKP 591
            |            .:.|...:::..:|..|.|..|  |.|::||..:.:..|:.:.:|:|:|.|.
Zfish   511 V------------TIFDKHSLRVLFHFAKDPPPARPDVLVVIISMLSSAPLPITNVRFQAAVPKN 563

  Fly   592 CKVRLLTPTDSQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGDD 643
            .:|:|..|:.|.:|...|..|...|.||:||.||..:.|.:...:.:.:|::
Zfish   564 MRVKLQPPSGSDLPAFNPVLPPAAITQVLLLANPHKEKVRLRYKLTFDIGEE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	53/137 (39%)
		GAT	210..284	CDD:281166	23/75 (31%)
		Alpha_adaptinC2	543..644	CDD:197886	30/103 (29%)
gga1	NP_001004000.2	VHS_GGA	9..147	CDD:239624	53/137 (39%)
		GAT_GGA1_GGA2	210..298	CDD:260097	26/88 (30%)
		Alpha_adaptinC2	513..627	CDD:197886	30/103 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574141
Domainoid	1	1.000	111	1.000	Domainoid score	I6180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3560
OMA	1	1.010	-	-		QHG51934
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm25303
orthoMCL	1	0.900	-	-		OOG6_106478
Panther	1	1.100	-	-	O	PTHR45905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940