DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gga and Gga2

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_083034.1	Gene:	Gga2 / 74105	MGIID:	1921355	Length:	603	Species:	Mus musculus

Alignment Length:	665	Identity:	170/665 - (25%)
Similarity:	299/665 - (44%)	Gaps:	137/665 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPAQ-KIDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLEECM 71
            :|..|.:||:|:. :.|...:|.||..|.::......|..::..|::|....||..|:::||.||
Mouse    29 LELWLNKATDPSMAEQDWSAIQKFCEQVNTDPSGPTHAPWLLAHKIQSPQEKEALYALTVLEICM 93

  Fly    72 TQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAYDML 136
            ..||:.|..|.:|||||||||:::|.||.||....:||.|::|.|..||..||:..||||||.||
Mouse    94 NHCGEKFHSEVAKFRFLNELIKVLSPKYLGAWATEKVKGRVIEILFSWTVWFPEDIKIRDAYQML 158

  Fly   137 RKEGDIEHGTTEAAVAK--------RESVLGTIDE--AMFAKLIKSNNPENFKRANLLLQYRMAQ 191
            :|:|.|:. ..:..:.|        .:|:....:|  .:..:|:|||:||:.:.||.|::..:.:
Mouse   159 KKQGIIKQ-DPKLPMDKILPPPSPWPKSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKE 222

  Fly   192 EARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDV--SETLHELYKSCKKHKP-IFQHLPQ 253
            |..:::.:::....:.||:..:::|.:||..|......:  .:.|..:|:.|:|.:| :|:....
Mouse   223 EQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQALQVVYERCEKLRPTLFRLASD 287

  Fly   254 LLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTASSTTATTS 318
            ..||.||  :|:.|.||..|...::.||.:|                             ....|
Mouse   288 TTDDDDA--LAEILQANDLLTQGVRLYKQVV-----------------------------EGRVS 321

  Fly   319 SNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSN-PLADL-------SDIFSSALAESEA 375
            :.||  :...:|          |..|..:.||....|.| ||.||       .|:  :||..::.
Mouse   322 AGNA--VPAAVG----------AIPAPRAFPNPEPCGLNCPLIDLETPSLLHQDL--AALGINDV 372

  Fly   376 KQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDMLSEELFQQILPTQD 440
            ..::|       ::.|...:......|:....||..|...:  |.:  :|:.|.:      |:
Mouse   373 PTRNQ-------VVIPSCCNDKKQPGAITLMGGGIQSLSAD--RNL--LDLFSPQ------PS-- 418

  Fly   441 RMPSFKRDPEKITLNDLARERMHIKAPEE--PTTANDPA-SDSAPAIATATATVDSIDDVPLLSD 502
              |.....|:|             ..|:|  |.|...|. |..|..:|::||:.::
Mouse   419 --PGLNYVPQK-------------SIPKEVPPGTKASPGWSWEAGPLASSTASQNT--------- 459

  Fly   503 DVEKKDEAVVAPVTVVPPAKPLSEINVELDNIQATGEQRIVL-DDDDMQLSLNFT-SDRPGH-RV 564
                                ||:.:.|.|::::.:....||: |.:..::.|:|: :..||| .|
Mouse   460 --------------------PLAHVFVPLESVKPSSLPPIVVYDRNGFRILLHFSQTGAPGHPDV 504

  Fly   565 SVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATPINQVMLLLNPTGKA 629
            .|::::..:.:.|||.|..|:.:|.|..:|:|...:.|::|...|..|...|:|.:||.||..:.
Mouse   505 KVLLLTMMSTATQPVWDVMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQTLLLDNPHKEP 569

  Fly   630 VDVTCIVGYKLGDDP 644
            :.:...:.:..|..|
Mouse   570 IRLRYKLTFNQGGQP 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	58/136 (43%)
		GAT	210..284	CDD:281166	21/76 (28%)
		Alpha_adaptinC2	543..644	CDD:197886	29/103 (28%)
Gga2	NP_083034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		VHS_GGA2	29..166	CDD:340807	58/136 (43%)
		GGA_N-GAT	187..226	CDD:375735	11/38 (29%)
		GAT_SF	229..317	CDD:383514	24/118 (20%)
		Unstructured hinge	318..473		44/231 (19%)
		Alpha_adaptinC2	481..595	CDD:197886	29/104 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831177
Domainoid	1	1.000	109	1.000	Domainoid score	I6354
eggNOG	1	0.900	-	-		E1_KOG1086
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3770
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51934
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm42851
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890