DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gga and Tom1l1

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001344472.1	Gene:	Tom1l1 / 71943	MGIID:	1919193	Length:	474	Species:	Mus musculus

Alignment Length:	439	Identity:	91/439 - (20%)
Similarity:	173/439 - (39%)	Gaps:	86/439 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLERATNPAQKIDELGVQM-FCIVVKSNAQLVHKAQEMIVAKV-RSTNVTEATRAISLLEECMTQ 73
            ::|:||......::.|..: .|.::.:.......|.:.:..:: ::.|..|...::||::.|:..
Mouse    18 LIEKATFAGVLTEDWGQFLHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLSLSLIDMCVQN 82

  Fly    74 CGDDFQDEASKFRFLNE-LIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFP---QRQKIRDAY- 133
            ||..||....|..|:.: |::|::.:|   ..|.|.:.||:..:..|:..||   ...::::.|
Mouse    83 CGPSFQSLIVKKEFIKDTLVKLLNPRY---TLPLETQNRILNFIKTWSQGFPGGVDVSEVKEVYL 144

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARRNDL 198
            |:|:|  .::...::.....|:.          |..|..|.|.:...|..|           :.:
Mouse   145 DLLKK--GVQFPPSDGEPETRQE----------AGQISPNRPTSVPTAPAL-----------SSI 186

  Fly   199 LAQHRLVLCEVQETMQLLNQMLD----------------TYDPANQDVSETLHELYKSCKKHKPI 247
            :|.....:..|.|.:..|:..||                |....|.:..|.|.:|||:.::.:..
Mouse   187 IAPKNPTISLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIELLRKLYKTGREMQER 251

  Fly   248 FQHLPQLLDDSDA--QLVADTLDANCALLA----TMQRYKLLVPSPTRSTAAALTTSAPTV---- 302
            ...|..::::.|.  :|:....|.|.|:|.    |..:.:||.....| |.|..|:|.|:.
Mouse   252 IMDLLVVVENEDVTMELIQVNEDLNNAVLGYERFTRNQQRLLEQKRNR-TEATRTSSEPSAPSCD 315

  Fly   303 ---ASSVKSTASSTTATTSSNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSNPLADL-- 362
               .|.:....:......:|.||||            |..:.::.:..:.|.......|..||
Mouse   316 LLDLSPIVPVPTPNEGALNSVNAQL------------SGLSVSSLSPVITNNLYPSLQPQRDLLA 368

  Fly   363 -SDI-----FSSALAESEAKQQS-QPFQNATTLLEPQVISQGTTTEALA 404
             .||     |....:::.|...: ..|.:.:.||:|  :|..|.|.|.|
Mouse   369 SEDIEIPTLFPQRTSQNLASSHTYDNFHSNSVLLQP--VSLHTATAAAA 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	31/139 (22%)
		GAT	210..284	CDD:281166	20/95 (21%)
		Alpha_adaptinC2	543..644	CDD:197886
Tom1l1	NP_001344472.1	VHS_ENTH_ANTH	14..154	CDD:321980	31/140 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..180		5/36 (14%)
		GAT_TM1L1	198..289	CDD:260095	19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..317		8/26 (31%)
		Interaction with GRB2	392..395		0/2 (0%)
		SH3-binding	420..424
		Interaction with PIK3R1	441..444
		SH2-binding	457..460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831168
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850