DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gga and tom1l2

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_009304960.1	Gene:	tom1l2 / 560327	ZFINID:	ZDB-GENE-061013-3	Length:	527	Species:	Danio rerio

Alignment Length:	554	Identity:	105/554 - (18%)
Similarity:	211/554 - (38%)	Gaps:	117/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LERATNPAQKIDELGVQM-FCIVVKSNAQLVHKAQEMIVAKVR-STNVTEATRAISLLEECMTQC 74
            :||||:.:.:.::..:.| .|.::.........|...:..::. :.|..|....:::||.|:..|
Zfish    17 IERATDGSLQSEDWTLNMEICDIINETEDGPKDAMRAVKKRLNGNKNYREVMLTLTVLETCVKNC 81

  Fly    75 GDDFQDEASKFRFLN-ELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEF---PQRQKIRDAYDM 135
            |..|....:...|:: .|::::|.|   ...|..|:.:::..:..|...|   |....:...|:.
Zfish    82 GYRFHMLVTTRDFIDGVLVKIISPK---NNPPAIVQDKVLALIQAWADAFRSSPDLTGVVHVYEE 143

  Fly   136 LRKEGDIEHGTTEAA------VAKRESVLGTIDEAMFAKLIKSN---NPENFKRANLLLQYRMAQ 191
            ::::| ||...:|..      ..:|:.....:|:..::..::..   :|.:.......:.:...|
Zfish   144 MKRKG-IEFPRSELETLSPIHTPQRQQTAPEMDQQKYSAPVQPKPQPHPASAPPFTAPVAHTSPQ 207

  Fly   192 EARRN---------DLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDVS--ETLHELYKSCKKHK 245
            ....:         :.:.:.|..|..|:...:::::||....|..:|.|  |.|.||.::|:..:
Zfish   208 MPNLHIAGPINPSPEQICKLRSELDIVRGNTKVMSEMLTEMVPGQEDPSDHELLQELNRTCRAMQ 272

  Fly   246 PIFQHLPQLLDD-SDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKST 309
               |.:.:|:.. |:.::..:.|..|..|.....||:                       ..:..
Zfish   273 ---QRIVELISRVSNEEVTEELLHVNDDLNNIFLRYE-----------------------RYERF 311

  Fly   310 ASSTTATTSSNN-AQLLNELLGDLLID--------GSNKAATTATTSLPNAAA------------ 353
            .|..||...:|. .::|||...|.|||        .|.:.:.|..:|||.:.|
Zfish   312 RSGRTAQGVNNGLREVLNEATEDNLIDLGPGSPAVVSPRISATPPSSLPPSVAPVRSASPVTLSS 376

  Fly   354 ----------SGSNPLADLS--------DIFSSALAESEAKQQSQPFQN--ATTLLEPQV-ISQG 397
                      |.|..|:.|:        |:|:.....:..:.:|.||::  |::.:.|.: :.|.
Zfish   377 RLAGLDVGSDSVSGTLSSLATCQPQDDFDMFAQTRTGTVPEWKSAPFEDTKASSGVAPTLDVRQQ 441

  Fly   398 TTTEALANGNGGSASKVPETIRKMPQIDMLSEELFQQILPTQDRMPSFKRDPEKITLNDLARERM 462
            ..|.||      ..|.|.:.|.:....|:..:|..:.:  |.:....|..:..|      |.|.:
Zfish   442 NATAAL------DQSSVMDDIEEWLSTDVKGDEGEEGV--TSEEFDKFLEERAK------AAEMV 492

  Fly   463 HIKAPEEPTTANDPASDSAPAIATATATVDSIDD 496
                |..||...|..|.:|.:.|.|:......:|
Zfish   493 ----PTLPTPPTDELSAAAGSSANASKKTGRSED 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	27/137 (20%)
		GAT	210..284	CDD:281166	18/76 (24%)
		Alpha_adaptinC2	543..644	CDD:197886
tom1l2	XP_009304960.1	VHS_Tom1	12..152	CDD:239623	28/138 (20%)
tom1l2	XP_009304960.1	GAT_TM1L2	221..312	CDD:260096	21/116 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.870