DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gga and gga3a

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001082823.2	Gene:	gga3a / 492643	ZFINID:	ZDB-GENE-041111-218	Length:	699	Species:	Danio rerio

Alignment Length:	746	Identity:	186/746 - (24%)
Similarity:	314/746 - (42%)	Gaps:	167/746 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPAQKIDE----LGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLE 68
            :|..|.:||||:.:.:|    :|   ||..:....:....:..::..|::|....|:.:|:::||
Zfish     9 LESWLNKATNPSNRQEEWEYIIG---FCDQINKELEGPQISVRLLAHKIQSPQEWESLQALTVLE 70

  Fly    69 ECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAY 133
            .||..||..|.:|..|||||||||:|||.||.|......||.:::|.|...:...|...||.:||
Zfish    71 ACMKNCGGRFHNEVGKFRFLNELIKLVSPKYLGDRVSERVKTKVIELLYNCSVALPDEAKIAEAY 135

  Fly   134 DMLRKEG----DIEHGTTEAAVAKRESVLGTID----EAMFAKLIKSNNPENFKRANLLLQYRMA 190
            .||:|:|    |.|.......:...::.....|    ....|:|:||..||:.:.||.:::..:.
Zfish   136 HMLKKQGIVTKDPEVHVDRTLIPSPKTKNPVFDNEEKSKRLAELLKSKKPEDLQEANRIIKNMVK 200

  Fly   191 QEARRNDLLAQHRLVLCEVQETMQLLNQMLDTY--DPANQDVSETLHELYKSCKKHKPIFQHLPQ 253
            ::......::.....|.:|..:::|||:||..:  |.:.|:..|.|.:||..|...:.....|..
Zfish   201 EDEALQQKVSNRVSTLEKVNNSVKLLNEMLSHFKTDESTQEDKELLKDLYNDCDNLRTAVFRLAT 265

  Fly   254 LLDDSDAQLVADTLDANCALLATMQRYKLLV---------------------------------- 284
            ..:|.|:.| .|.|.|:..|...:..||.:|
Zfish   266 ETEDDDSAL-GDILHASDDLSRVINSYKKIVEGQTIVIDVPASTPSGCINDRSSSEILIDLADLG 329

  Fly   285 ---PSPTR----------STAAALTT------SAPTVASSVKSTASSTTATTSS---NNAQLLNE 327
               |||.|          |.||.|.|      :.|:.:::...::|..|:..||   ::..||:|
Zfish   330 SGTPSPLRHGLTPPQHSDSPAADLLTLTSLMGAQPSSSNTSSGSSSFQTSPPSSQLPSSLSLLDE 394

  Fly   328 LLGDL---LIDGSNKAATTATTSLPNA----AASGSNPLADLSDIFSSALAESEAKQQSQPFQNA 385
            .||..   .:|.:::.:...||....:    ::..|||   ::|...|:...:.....:.|....
Zfish   395 ELGSFGLGSLDSNSRTSAEKTTKEAQSNQWISSQISNP---VTDFLCSSTPLNPPNSAAPPTSKT 456

  Fly   386 TTLLEPQ----------VISQGTTTEALANGNGGSASKV---PETIRKMPQIDMLSEELFQQILP 437
            |::.:.:          |:.....|::|:|.:..|:.::   .|.|.  |.::.||  |...|.|
Zfish   457 TSITDFENSLQQSFKDLVLLDLDKTKSLSNYSSLSSRELAAGKENIH--PALNTLS--LSAGITP 517

  Fly   438 TQDRMPSFKRDPEKITLNDLARERMHIKAPEEPT----TANDPASDSAPAIATATATVDSIDDVP 498
            ......|.|  |:..             ||:.|.    :...|:|.|:           |..|:.
Zfish   518 LPSAGSSAK--PQSF-------------APDSPVFRSLSPTLPSSQSS-----------SGSDIS 556

  Fly   499 LLSDDVEKKDEAVVAPVTVVPPAK--PLSEINVELDNIQATGEQRIVLDDDDMQLSLNFTSDRPG 561
            |.|         |..|:..:.|:|  |::                 ..|.|.:::.|:|.:|.|.
Zfish   557 LTS---------VFVPLEAIKPSKECPVT-----------------AYDKDGVRVLLHFATDHPT 595

  Fly   562 HR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATPINQVMLLLN 624
            .|  |.|||:|..|.:...||:...:|:|.|..:|:|..|:.::|.|..||.|.:.|.|:|||.|
Zfish   596 GRPDVLVIVVSMLNTAPLLVRNVMLQAAVPKSMRVKLQPPSGTEMAPFNPFMPPSSITQIMLLAN 660

  Fly   625 PTGKAVDVTCIVGYKLGDDPDPIKESIVAKG 655
            |..:.|.:...:.:.|||.|      :.|.|
Zfish   661 PLKEKVRMRYKLTFILGDQP------VTASG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	51/143 (36%)
		GAT	210..284	CDD:281166	22/75 (29%)
		Alpha_adaptinC2	543..644	CDD:197886	37/102 (36%)
gga3a	NP_001082823.2	VHS_GGA	8..145	CDD:239624	50/138 (36%)
		GAT_SF	212..297	CDD:322464	25/85 (29%)
		Alpha_adaptinC2	577..691	CDD:197886	40/115 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574137
Domainoid	1	1.000	111	1.000	Domainoid score	I6180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3560
OMA	1	1.010	-	-		QHG51934
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm25303
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.000