DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and Tom1

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001008366.1	Gene:	Tom1 / 361370	RGDID:	1308024	Length:	492	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	117/545 - (21%)
Similarity:	202/545 - (37%)	Gaps:	128/545 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EMLERATNPAQKIDELGVQM-FCIVVKSNAQLVHKAQEMIVAK-VRSTNVTEATRAISLLEECMT 72
            :.:|:||:.:.:.::..:.| .|.::....:....|...:..: |.:.|..|...|:::||.|:.
  Rat    15 QRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIVGNKNFHEVMLALTVLETCVK 79

  Fly    73 QCGDDFQDEASKFRFL-NELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEF---PQRQKIRDAY 133
            .||..|....:...|: |.|:|.:..|   ...|..|..:::..:..|...|   |....:...|
  Rat    80 NCGHRFHVLVASQDFVENVLVRTILPK---NNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVAVY 141

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARRNDL 198
            :.||::| :|...|:..:.   |.:.|....:|       |.|...|.|.:    ::..:.|.|
  Rat   142 EDLRRKG-LEFPMTDLDML---SPIHTPQRTVF-------NSETPSRQNPV----VSNSSHRGD- 190

  Fly   199 LAQH--------------------------RLVLCEVQETMQLLNQMLDTYDPANQDVS--ETLH 235
            |:||                          |..|..|...::::::||....|...:.:  |.|.
  Rat   191 LSQHATPLPTPAVLPGDSPITPTPEQIGKLRSELEMVNGNVRVMSEMLTELVPTQVEPADLELLQ 255

  Fly   236 ELYKSCK-KHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSA 299
            ||.::|: ..:.|.:.:|::   |:.||..:.|..|..|.....|::......|..||.|
  Rat   256 ELNRTCRAMQQRILELIPRI---SNEQLTEELLMINDNLNNVFLRHERFERFRTGQTAKA----- 312

  Fly   300 PTVASSVKSTASSTTATTSSNNAQLLNELLGDLLIDGSNKAATTATTS---------------LP 349
                               |..|    ||..||:..|.:.|||:..:|               |.
  Rat   313 -------------------SGEA----ELAADLIDMGPDPAATSNLSSQLAGVDLGSSRVRAGLQ 354

  Fly   350 NAAASGSNPLADLSDIFSSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKV 414
            :..|||.  |.|..|:|:.....|.|.|:......|     ||      ||:.||    |:....
  Rat   355 SLEASGH--LEDDFDMFALTRGSSLADQRKGVKYEA-----PQ------TTDGLA----GALDAR 402

  Fly   415 PETIRKMPQIDMLSEELFQQILPTQDRMPSFKRDPEKITLNDLAR---ERMHIKAPEEPTTANDP 476
            .::...:|.......|..:|.|.|.  :.|...:|..:|..:..:   ||  .||.:.......|
  Rat   403 QQSTGAIPATQARIMEDIEQWLSTD--VGSSAEEPSGVTSEEFDKFLEER--AKAADRLPNLASP 463

  Fly   477 ASDS----APAIATATATVDSIDDV 497
            :::.    .|..|....|.:..|||
  Rat   464 SAEGPPRPCPGAAPRRKTQEKDDDV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	30/139 (22%)
		GAT	210..284	CDD:281166	17/76 (22%)
		Alpha_adaptinC2	543..644	CDD:197886
Tom1	NP_001008366.1	VHS_Tom1	12..152	CDD:239623	31/140 (22%)
Tom1	NP_001008366.1	GAT_TOM1	214..308	CDD:260094	21/96 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850