DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and Gga3

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_006247781.1	Gene:	Gga3 / 360658	RGDID:	1309553	Length:	727	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	189/756 - (25%)
Similarity:	314/756 - (41%)	Gaps:	179/756 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPAQKIDE----LGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLE 68
            :|..|.:||||:.:.::    :|   ||..:....:....|..::..|::|....||.:|:::||
  Rat     9 LESWLNKATNPSNRQEDWEYIIG---FCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLE 70

  Fly    69 ECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAY 133
            .||..||....:|..|||||||||::||.||.|.....:||.:::|.|..||...|:..||:|||
  Rat    71 ACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKAKVIELLFSWTLALPEEAKIKDAY 135

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGT----------IDE---AMFAKLIKSNNPENFKRANLLL 185
            .||:::|.::   ::..:....:::.:          .||   .:.|||::|.||::.:.||.|:
  Rat   136 HMLKRQGIVQ---SDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLRSKNPDDLQEANQLI 197

  Fly   186 QYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDVS-----ETLHELYKSCK-KH 244
            :..:.::..|...:.:....|.||...::||::||..|   :|:.|     |.:.||:..|: |.
  Rat   198 KSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHY---SQEFSSEADKELMKELFDRCENKR 259

  Fly   245 KPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSP------TRSTA----------- 292
            :.:|: |....:|:|..| .|.|.|:..|...:..||.::...      |.||.
  Rat   260 RTLFK-LASETEDNDNSL-GDILQASDNLSRVINSYKTIIEGQIINGEVTTSTVPDSEGNSHCGN 322

  Fly   293 -------AALTT---SAPTVA------------------------SSVKSTASSTTATTSSNNA- 322
                   |.|.|   |:|.:|                        |...|.|.:.:...|:|||
  Rat   323 QGALIDLAELDTPSSSSPVLAPAPAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPSGPDSTNNAL 387

  Fly   323 QLLNELLGDLLIDGSNKAATTATTSLPNAAASGS-------NPLADLSDIFSSALAESEAKQQSQ 380
            .||:|   :||..|.:..|.||    |..:|..|       .|.:|| |.||..|..:    .|.
  Rat   388 SLLDE---ELLCLGLSDPAPTA----PKESAGNSPWHLFQNEPSSDL-DFFSPRLVSA----ASC 440

  Fly   381 PFQNATTLLEPQV----ISQG----------TTTEALANGNGG---SASKVPETIRKMPQIDMLS 428
            |.:.  :||.|.|    :||.          ....|:.:..|.   |:...|..:.|..
  Rat   441 PSEG--SLLPPPVSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAE------ 497

  Fly   429 EELFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVDS 493
                    |.....||.........|:.|..|........:|.:...|...::|.:..:|..
  Rat   498 --------PEGPEYPSSSISHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPA--- 551

  Fly   494 IDDVPLLSDDVEKKDEAVVAPVTVVP-------------------PAKPLSEINVELDNIQATGE 539
               .|||             |.:..|                   |...|:.::|.|::|:.:..
  Rat   552 ---RPLL-------------PFSTGPGSPLFQSPAFQSQGSPQKGPELSLASVHVPLESIKPSSA 600

  Fly   540 QRI-VLDDDDMQLSLNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTD 601
            ..: ..|.:..::..:|..:.|..|  |.|:|:|..|.:..||:....:|:|.|..||:|..|:.
  Rat   601 LPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSG 665

  Fly   602 SQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGD 642
            :::.|..|.:|...|.|||||.||..:.|.:...:.:.||:
  Rat   666 TELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGE 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	51/139 (37%)
		GAT	210..284	CDD:281166	23/79 (29%)
		Alpha_adaptinC2	543..644	CDD:197886	32/102 (31%)
Gga3	XP_006247781.1	VHS_GGA	8..146	CDD:239624	51/142 (36%)
		GAT_GGA3	213..299	CDD:260098	26/90 (29%)
		Alpha_adaptinC2	605..719	CDD:197886	32/102 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334895
Domainoid	1	1.000	111	1.000	Domainoid score	I6100
eggNOG	1	0.900	-	-		E1_KOG1086
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4016
OMA	1	1.010	-	-		QHG51934
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm44916
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910