Protein Alignment Gga and Gga3

DIOPT Version :10

• Sequence 1: NP_572571.1
• Gene: Gga / 31902
• FlyBaseID: FBgn0030141
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_001402615.1
• Gene: Gga3 / 360658
• RGDID: 1309553
• Length: 727
• Species: Rattus norvegicus
• Alignment Length: 756
• Identity: 189/756 - (25%)
• Similarity: 314/756 - (41%)
• Gaps: 179/756 - (23%)

  Fly     8 MEEMLERATNPAQKIDE----LGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLE 68
            :|..|.:||||:.:.::    :|   ||..:....:....|..::..|::|....||.:|:::||
  Rat     9 LESWLNKATNPSNRQEDWEYIIG---FCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLE 70

  Fly    69 ECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAY 133
            .||..||....:|..|||||||||::||.||.|.....:||.:::|.|..||...|:..||:|||
  Rat    71 ACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKAKVIELLFSWTLALPEEAKIKDAY 135

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGT----------IDE---AMFAKLIKSNNPENFKRANLLL 185
            .||:::|.::   ::..:....:::.:          .||   .:.|||::|.||::.:.||.|:
  Rat   136 HMLKRQGIVQ---SDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLRSKNPDDLQEANQLI 197

  Fly   186 QYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDVS-----ETLHELYKSCK-KH 244
            :..:.::..|...:.:....|.||...::||::||..|   :|:.|     |.:.||:..|: |.
  Rat   198 KSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHY---SQEFSSEADKELMKELFDRCENKR 259

  Fly   245 KPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSP------TRSTA----------- 292
            :.:|: |....:|:|..| .|.|.|:..|...:..||.::...      |.||.
  Rat   260 RTLFK-LASETEDNDNSL-GDILQASDNLSRVINSYKTIIEGQIINGEVTTSTVPDSEGNSHCGN 322

  Fly   293 -------AALTT---SAPTVA------------------------SSVKSTASSTTATTSSNNA- 322
                   |.|.|   |:|.:|                        |...|.|.:.:...|:|||
  Rat   323 QGALIDLAELDTPSSSSPVLAPAPAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPSGPDSTNNAL 387

  Fly   323 QLLNELLGDLLIDGSNKAATTATTSLPNAAASGS-------NPLADLSDIFSSALAESEAKQQSQ 380
            .||:|   :||..|.:..|.||    |..:|..|       .|.:|| |.||..|..:    .|.
  Rat   388 SLLDE---ELLCLGLSDPAPTA----PKESAGNSPWHLFQNEPSSDL-DFFSPRLVSA----ASC 440

  Fly   381 PFQNATTLLEPQV----ISQG----------TTTEALANGNGG---SASKVPETIRKMPQIDMLS 428
            |.:.  :||.|.|    :||.          ....|:.:..|.   |:...|..:.|..
  Rat   441 PSEG--SLLPPPVSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAE------ 497

  Fly   429 EELFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVDS 493
                    |.....||.........|:.|..|........:|.:...|...::|.:..:|..
  Rat   498 --------PEGPEYPSSSISHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPA--- 551

  Fly   494 IDDVPLLSDDVEKKDEAVVAPVTVVP-------------------PAKPLSEINVELDNIQATGE 539
               .|||             |.:..|                   |...|:.::|.|::|:.:..
  Rat   552 ---RPLL-------------PFSTGPGSPLFQSPAFQSQGSPQKGPELSLASVHVPLESIKPSSA 600

  Fly   540 QRI-VLDDDDMQLSLNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTD 601
            ..: ..|.:..::..:|..:.|..|  |.|:|:|..|.:..||:....:|:|.|..||:|..|:.
  Rat   601 LPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSG 665

  Fly   602 SQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGD 642
            :::.|..|.:|...|.|||||.||..:.|.:...:.:.||:
  Rat   666 TELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGE 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA_metazoan	8..144	CDD:340769	51/139 (37%)
		GAT_GGA_meta	201..283	CDD:410582	26/87 (30%)
		Alpha_adaptinC2	543..644	CDD:197886	32/102 (31%)
Gga3	NP_001402615.1	VHS_GGA3	6..146	CDD:340805	51/142 (36%)
		GGA_N-GAT	169..207	CDD:465702	11/37 (30%)
		GAT_GGA3	213..299	CDD:410587	26/90 (29%)
		Unstructured hinge. /evidence=ECO:0000250|UniProtKB:Q8BMI3	299..597		68/344 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..385		8/50 (16%)
		DXXLL	391..395		1/6 (17%)
		PHA03247	<399..595	CDD:223021	45/239 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..419		6/22 (27%)
		Alpha_adaptinC2	605..719	CDD:197886	32/102 (31%)