DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and Gga3

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_766636.2	Gene:	Gga3 / 260302	MGIID:	2384159	Length:	718	Species:	Mus musculus

Alignment Length:	742	Identity:	184/742 - (24%)
Similarity:	317/742 - (42%)	Gaps:	160/742 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPAQKIDE----LGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLE 68
            :|..|.:||||:.:.::    :|   ||..:....:....|..::..|::|....||.:|:::||
Mouse     9 LESWLNKATNPSNRQEDWEYIIG---FCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLE 70

  Fly    69 ECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAY 133
            .||..||....:|..|||||||||::||.||.|.....:||.:::|.|..||...|:..||:|||
Mouse    71 ACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLFSWTLALPEEAKIKDAY 135

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGT----------IDE---AMFAKLIKSNNPENFKRANLLL 185
            .||:::|.::   ::..:....:::.:          .||   .:.|:|:||.||::.:.||.|:
Mouse   136 HMLKRQGIVQ---SDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLARLLKSKNPDDLQEANRLI 197

  Fly   186 QYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDVS-----ETLHELYKSCK-KH 244
            :..:.::..|...:.:....|.||...::||::||..|   :|:.|     |.:.||:..|: |.
Mouse   198 KSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHY---SQEYSSDADKELMKELFDRCENKR 259

  Fly   245 KPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSP------TRSTAA---------- 293
            :.:|: |....:|:|..| .|.|.|:..|...:..||.::...      |.||..
Mouse   260 RTLFK-LASETEDNDNSL-GDILQASDNLSRVINSYKTIIEGQIVNGEVTTSTMPDSEGNSHCGN 322

  Fly   294 -----------ALTTSAPTVA--------------------SSVKSTASSTTATTSSNNA-QLLN 326
                       |.:.|:|.:|                    |...|.|.:...:.|:||| .||:
Mouse   323 QGALIDLAELDAPSNSSPALAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPPGSDSTNNALSLLD 387

  Fly   327 ELLGDLLIDGSNKAATTATTSLPNAA---ASGSNPLADLSDIFS-----SALAESEAKQQSQPFQ 383
            |   :||..|....|.||....|.::   ...:.|.:|| |.||     :|...|:..|...|..
Mouse   388 E---ELLCLGLTDPAPTAPKESPGSSQWHLFQNEPPSDL-DFFSPRPVPAASCPSDGPQLPPPVS 448

  Fly   384 NATTLLEP-------QVISQGTTTEALAN---GNGGSASKVPETIRKMPQIDMLSEELFQQILPT 438
            .::....|       .|:.....|.:..:   .:|.:.:..|:...|.|:....|         |
Mouse   449 TSSMSQAPLPAAFPAPVVPASAPTHSTGSFMFSSGPAPALAPKAEPKGPEYPSSS---------T 504

  Fly   439 QDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAI-ATATATVDSIDDVPLLSD 502
            ..|:.:         |:.|..|........:|.:...|...::|.: |:|.|.       |||
Mouse   505 SHRLDA---------LDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASAPAR-------PLL-- 551

  Fly   503 DVEKKDEAVVAPVTVVP--------------PAKPLSEINVELDNIQATGEQRI-VLDDDDMQLS 552
                       |.:..|              |...|:.::|.|::|:.:....: ..|.:..::.
Mouse   552 -----------PFSTGPGSPLFQSQGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRIL 605

  Fly   553 LNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATP 615
            .:|..:.|..|  |.|:|:|..|.:..||:....:|:|.|..||:|..|:.:::.|..|.:|...
Mouse   606 FHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAA 670

  Fly   616 INQVMLLLNPTGKAVDVTCIVGYKLGD 642
            |.|||||.||..:.|.:...:.:.||:
Mouse   671 ITQVMLLANPMKEKVRLRYKLTFALGE 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	51/139 (37%)
		GAT	210..284	CDD:281166	23/79 (29%)
		Alpha_adaptinC2	543..644	CDD:197886	32/102 (31%)
Gga3	NP_766636.2	VHS_GGA	8..146	CDD:239624	51/142 (36%)
		GAT_GGA3	213..299	CDD:260098	26/90 (29%)
		Unstructured hinge	299..588		63/330 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..381		8/46 (17%)
		Autoinhibitory. /evidence=ECO:0000250	387..391		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..455		14/60 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..506		6/37 (16%)
		Alpha_adaptinC2	596..710	CDD:197886	32/102 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831174
Domainoid	1	1.000	109	1.000	Domainoid score	I6354
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3770
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51934
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm42851
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	13.000