DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and GGA3

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_016879874.1	Gene:	GGA3 / 23163	HGNCID:	17079	Length:	733	Species:	Homo sapiens

Alignment Length:	736	Identity:	181/736 - (24%)
Similarity:	310/736 - (42%)	Gaps:	177/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPAQKIDE----LGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLE 68
            :|..|.:||||:.:.::    :|   ||..:....:....|..::..|::|....||.:|:::||
Human     9 LESWLNKATNPSNRQEDWEYIIG---FCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLE 70

  Fly    69 ECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAY 133
            .||..||..|.:|..|||||||||::||.||.|.....:||.:::|.|..||...|:..||:|||
Human    71 ACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAY 135

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGT----------IDE---AMFAKLIKSNNPENFKRANLLL 185
            .||:::|.::   ::..:....:::.:          .||   .:.|||:||.||::.:.||.|:
Human   136 HMLKRQGIVQ---SDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLI 197

  Fly   186 QYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTY---DPANQDVSETLHELYKSCK-KHKP 246
            :..:.::..|...:.:....|.||...::||::||..|   |.::.| .|.:.||:..|: |.:.
Human   198 KSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGD-RELMKELFDQCENKRRT 261

  Fly   247 IFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTAS 311
            :|: |....:|:|..| .|.|.|:..|...:..||.::....                 :....:
Human   262 LFK-LASETEDNDNSL-GDILQASDNLSRVINSYKTIIEGQV-----------------INGEVA 307

  Fly   312 STTATTSSNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIF---------- 366
            :.|...|..|:|..|:  |.|:    :.|....|.||.:..|....|.:....|.
Human   308 TLTLPDSEGNSQCSNQ--GTLI----DLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPP 366

  Fly   367 -SSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVP--ETI---------R 419
             |.:.:::||........||.:.|:.:::..|     ||:    .|..||  |:.         |
Human   367 RSRSSSQAEATLGPSSTSNALSWLDEELLCLG-----LAD----PAPNVPPKESAGNSQWHLLQR 422

  Fly   420 KMPQIDMLSEE------------LFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTT 472
            :...:|..|..            |.|...|:.....:....|              ..||..|.:
Human   423 EQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPP--------------FPAPVVPAS 473

  Fly   473 ANDPASDS-------APAIA-----------------TATATVDSIDDVPLLSDDVEKKDEAVVA 513
            ...|::.|       |||:|                 :|...:|::|.  ||.:  .|....:|.
Human   474 VPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQ--LLEE--AKVTSGLVK 534

  Fly   514 PVT--VVP---PAKP-------------------------------LSEINVELDNIQATGEQRI 542
            |.|  ::|   ||:|                               |:.|:|.|::|:.:....:
Human   535 PTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPV 599

  Fly   543 -VLDDDDMQLSLNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQM 604
             ..|.:..::..:|..:.|..|  |.|:|:|..|.:..||:....:|:|.|..||:|..|:.:::
Human   600 TAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTEL 664

  Fly   605 PPHKPFRPATPINQVMLLLNP 625
            .|..|.:|...|.|||||.||
Human   665 SPFSPIQPPAAITQVMLLANP 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	52/139 (37%)
		GAT	210..284	CDD:281166	23/77 (30%)
		Alpha_adaptinC2	543..644	CDD:197886	29/85 (34%)
GGA3	XP_016879874.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141230
Domainoid	1	1.000	111	1.000	Domainoid score	I6233
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3724
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51934
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm40777
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.040