DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and GGA2

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_055859.1	Gene:	GGA2 / 23062	HGNCID:	16064	Length:	613	Species:	Homo sapiens

Alignment Length:	667	Identity:	168/667 - (25%)
Similarity:	297/667 - (44%)	Gaps:	128/667 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPA-QKIDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLEECM 71
            :|..|.:||:|: .:.|...:|.||..|.::......|..::..|::|....||..|:::||.||
Human    26 LELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCM 90

  Fly    72 TQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAYDML 136
            ..||:.|..|.:|||||||||:::|.||.|:....:||.|::|.|..||..||:..||||||.||
Human    91 NHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQML 155

  Fly   137 RKEGDIEHGTTEAAVAK---------RESVLGTIDE--AMFAKLIKSNNPENFKRANLLLQYRMA 190
            :|:|.|:. ..:..|.|         :.|:....:|  .:..:|:|||:||:.:.||.|::..:.
Human   156 KKQGIIKQ-DPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVK 219

  Fly   191 QEARRNDLLAQHRLVLCEVQETMQLLNQMLDTY-----DPANQDVSETLHELYKSCKKHKP-IFQ 249
            :|..:::.:::....:.||:..:::|.:||..|     .|.:|   |.|..:|:.|:|.:| :|:
Human   220 EEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQ---EALQVVYERCEKLRPTLFR 281

  Fly   250 HLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTASSTT 314
            ......||.||  :|:.|.||..|...:..||.::..  |.|.....||:
Human   282 LASDTTDDDDA--LAEILQANDLLTQGVLLYKQVMEG--RVTFGNRVTSS--------------- 327

  Fly   315 ATTSSNNAQLLNELLGDLLID-------GSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAE 372
                          |||:.:.       |..|........:.|..|.....:..|.....:||..
Human   328 --------------LGDIPVSRVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGI 378

  Fly   373 SEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDMLSEELFQQILP 437
            |:|.        .|.::..|...:.....:.:...||.... |...|.:  :|:||.:
Human   379 SDAP--------VTGMVSGQNCCEEKRNPSSSTLPGGGVQN-PSADRNL--LDLLSAQ------- 425

  Fly   438 TQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVDSIDDVPLLSD 502
                       |....||.::::.:..:.|        |.:.|:|..:.
Human   426 -----------PAPCPLNYVSQKSVPKEVP--------PGTKSSPGWSW---------------- 455

  Fly   503 DVEKKDEAVVAPVTVVPPAK--PLSEINVELDNIQATG-EQRIVLDDDDMQLSLNFT-SDRPGH- 562
                  ||  .|:...|.::  ||:::.|.|::::.:. ...||.|.:..::.|:|: :..|||
Human   456 ------EA--GPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHP 512

  Fly   563 RVSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATPINQVMLLLNPTG 627
            .|.|::::..:.:.|||.|..|:.:|.|..:|:|...:.|::|...|..|...|:|::||.||..
Human   513 EVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHK 577

  Fly   628 KAVDVTCIVGYKLGDDP 644
            :.:.:...:.:..|..|
Human   578 EPIRLRYKLTFNQGGQP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	57/136 (42%)
		GAT	210..284	CDD:281166	24/79 (30%)
		Alpha_adaptinC2	543..644	CDD:197886	29/102 (28%)
GGA2	NP_055859.1	VHS_GGA	25..163	CDD:239624	57/136 (42%)
		ATP-synt_B	168..>240	CDD:304375	16/71 (23%)
		GAT_GGA1_GGA2	227..315	CDD:260097	26/92 (28%)
		Unstructured hinge	316..483		40/258 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..414		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..466		8/62 (13%)
		Alpha_adaptinC2	491..605	CDD:197886	30/104 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141233
Domainoid	1	1.000	111	1.000	Domainoid score	I6233
eggNOG	1	0.900	-	-		E1_KOG1086
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3724
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51934
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm40777
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900