DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gga and Tom1

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001129731.1	Gene:	Tom1 / 21968	MGIID:	1338026	Length:	516	Species:	Mus musculus

Alignment Length:	543	Identity:	116/543 - (21%)
Similarity:	210/543 - (38%)	Gaps:	100/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EMLERATNPAQKIDELGVQM-FCIVVKSNAQLVHKAQEMIVAKVR-STNVTEATRAISLLEECMT 72
            :.:|:||:.:.:.::..:.| .|.::....:....|...:..::. :.|..|...|:::||.|:.
Mouse    15 QRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIMGNKNFHEVMLALTVLETCVK 79

  Fly    73 QCGDDFQDEASKFRFL-NELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEF---PQRQKIRDAY 133
            .||..|....:...|: |.|:|.:..|   ...|..|..:::..:..|...|   |....:...|
Mouse    80 NCGHRFHVLVANQDFVENVLVRTILPK---NNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVAVY 141

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARRNDL 198
            :.||::| :|...|:..:.   |.:.|....:|       |.|...|.|.:    .:..::|.|
Mouse   142 EDLRRKG-LEFPMTDLDML---SPIHTPQRTVF-------NSETPSRQNSV----SSNTSQRGD- 190

  Fly   199 LAQH--------------------------RLVLCEVQETMQLLNQMLDTYDPANQDVS--ETLH 235
            |:||                          |..|..|...::::::||....|...:.:  |.|.
Mouse   191 LSQHATPLPTPAVLPGDSPITPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQVEPADLELLQ 255

  Fly   236 ELYKSCK-KHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSA 299
            ||.::|: ..:.|.:.:|::   |:.||..:.|..|..|.....|::......|..||.|  :|.
Mouse   256 ELNRTCRAMQQRILELIPRI---SNEQLTEELLMINDNLNNVFLRHERFERFRTGQTAKA--SSE 315

  Fly   300 PTVASSVKSTASSTTATT--SSNNAQLLNELLG----DLLIDGSNK-------AATTATTSLPNA 351
            ..:|:.:........||.  ||..|.:.|.||.    .||.:|..:       .:.:....|.:.
Mouse   316 AELATDLIDMGPDPAATNNLSSQLAGMNNRLLSLSNHFLLEEGKKEWAPLQDLGSRSVRAGLQSL 380

  Fly   352 AASGSNPLADLSDIFSSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPE 416
            ..||.  |.|..|:|:.....|.|.|:......|     ||      ||:.||    |:.....:
Mouse   381 ETSGH--LEDDFDMFALTRGSSLADQRKGVKYEA-----PQ------TTDGLA----GALDARQQ 428

  Fly   417 TIRKMPQIDMLSEELFQQILPTQDRMPSFKRDPEKITLNDLAR---ERMHIKAPEEPTTANDPAS 478
            :...:|.......|..:|.|.|.  :.:...:|..:|..:..:   ||  .||.:.......|::
Mouse   429 STGAIPATQARIMEDIEQWLSTD--VGNSAEEPSGVTSEEFDKFLEER--AKAADRLPNLASPSA 489

  Fly   479 DSAPAIATATA----TVDSIDDV 497
            :..|..:..||    |.:..||:
Mouse   490 EGPPRPSPGTAPRRKTQEKDDDM 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	29/139 (21%)
		GAT	210..284	CDD:281166	17/76 (22%)
		Alpha_adaptinC2	543..644	CDD:197886
Tom1	NP_001129731.1	VHS_Tom1	12..152	CDD:239623	30/140 (21%)
Tom1	NP_001129731.1	GAT_TOM1	214..308	CDD:260094	21/96 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850