Protein Alignment Gga and Gga1

DIOPT Version :10

• Sequence 1: NP_572571.1
• Gene: Gga / 31902
• FlyBaseID: FBgn0030141
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_666041.1
• Gene: Gga1 / 106039
• MGIID: 2146207
• Length: 635
• Species: Mus musculus
• Alignment Length: 693
• Identity: 181/693 - (26%)
• Similarity: 315/693 - (45%)
• Gaps: 146/693 - (21%)

  Fly     8 MEEMLERATNPAQK-IDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLEECM 71
            :|..:.|||||..| ::...:..||..:..:.:....|..::..|::|....||.:|:::||.||
Mouse    10 LEARINRATNPLNKELNWASINSFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCM 74

  Fly    72 TQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRDAYDML 136
            ..||..|.||..|||||||||::||.||.|:.|..:||.:|:|.|..||...|:..||.:||.||
Mouse    75 KSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKSKILELLYSWTVCLPEEVKIAEAYQML 139

  Fly   137 RKEGDIEHG--TTEAAV-----AKRESVLGTIDE--AMFAKLIKSNNPENFKRANLLLQYRMAQE 192
            :|:|.::..  ..|.|:     .:.::|:...:|  .|.|:|:||::||:.:.||.|::..:.::
Mouse   140 KKQGIVKSDPKLPEDAIFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQED 204

  Fly   193 ARRNDLLAQHRLVLCEVQETMQLLNQMLDTYD--PANQDVSETLHELYKSCKKHKPIFQHLPQLL 255
            .:|.:.:::....:.||...::||.:|:.::.  .|:....:.:.|||:.|::.:|....|....
Mouse   205 QKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGAASSSSEDLMKELYQRCERMRPTLFRLASDT 269

  Fly   256 DDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTASSTTATTSSN 320
            :|:| :.:|:.|.||..|...:..||.||.....:..|               ||||...:||:
Mouse   270 EDND-EALAEILQANDNLTQVINLYKQLVRGEEVNGDA---------------TASSIPGSTSA- 317

  Fly   321 NAQLLNELLG-DLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAESEAKQQSQPFQN 384
                |.:|.| ||...|:.:.||      |....:.|:|                     :....
Mouse   318 ----LLDLSGLDLPPPGTTQPAT------PTRPGNQSSP---------------------EQLSA 351

  Fly   385 ATTLLEPQVIS---------QGTTTEALA----NGNGGSASKV------------------PETI 418
            :.:||:.:::|         .||:::::.    ..:.|:.|.|                  |.|.
Mouse   352 SVSLLDDELMSLGLSDPTPPSGTSSDSVGWDNFQSSDGTESSVPPPAQAPSMDCRPPAQAPPPTS 416

  Fly   419 RKMPQIDMLSEELFQQILPTQDRMPSF-KRDP-EKITLNDL----------ARERMHIKAPEEPT 471
            ..:..:|:|.:.|.||.||.:.:...: |:.| .::||.||          |...:|..:||.|
Mouse   417 SGLDDLDLLGKTLMQQALPPEAQQVRWEKQQPAPRLTLRDLQSKSSSPSPGAASLLHTTSPEPP- 480

  Fly   472 TANDPASDSAPAIATATATVDSIDDVPLLSDDVEKKDEAVVAPVTVVPPAKPLSEINVELDNIQA 536
               .|...:.|...:.|:..     |||.|          :.|.:::|..
Mouse   481 ---GPPPQATPTEFSLTSIT-----VPLES----------IKPSSILPVT--------------- 512

  Fly   537 TGEQRIVLDDDDMQLSLNFTSD-RPGHR-VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTP 599
                  |.|....::..:|..| .||.. |.|:|:|..:.:.||:|:..|:::|.|..||||..|
Mouse   513 ------VYDQHGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVRLQPP 571

  Fly   600 TDSQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGD 642
            :.:::|...|....:.|.||:||.||..:.|.:...:.:.:||
Mouse   572 SGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTMGD 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA_metazoan	8..144	CDD:340769	55/136 (40%)
		GAT_GGA_meta	201..283	CDD:410582	21/83 (25%)
		Alpha_adaptinC2	543..644	CDD:197886	33/102 (32%)
Gga1	NP_666041.1	VHS_GGA1	9..147	CDD:340806	55/136 (40%)
		Interaction with ARF3. /evidence=ECO:0000250	114..273		42/158 (27%)
		GGA_N-GAT	169..207	CDD:465702	11/37 (30%)
		GAT_GGA1_GGA2	210..297	CDD:410586	21/87 (24%)
		Unstructured hinge	299..505		53/271 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..349		18/90 (20%)
		Autoinhibitory. /evidence=ECO:0000250	357..361		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..422		8/59 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..490		9/38 (24%)
		Alpha_adaptinC2	513..627	CDD:197886	33/102 (32%)