DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gga and TOM1L1

DIOPT Version :9

Sequence 1:NP_572571.1 Gene:Gga / 31902 FlyBaseID:FBgn0030141 Length:660 Species:Drosophila melanogaster
Sequence 2:NP_005477.2 Gene:TOM1L1 / 10040 HGNCID:11983 Length:476 Species:Homo sapiens


Alignment Length:576 Identity:114/576 - (19%)
Similarity:207/576 - (35%) Gaps:155/576 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 MLERATNPAQKIDELGVQM-FCIVVKSNAQLVHKAQEMIVAKV-RSTNVTEATRAISLLEECMTQ 73
            ::|:||....:.::.|..| .|.::.:.......|.:.:..:: ::.|..|....:||::.|:..
Human    18 LIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQN 82

  Fly    74 CGDDFQDEASKFRFLNE-LIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFP---QRQKIRDAY- 133
            ||..||....|..|:.| |::|::.:|   ..|.:::.||:..:..|:..||   ...::::.| 
Human    83 CGPSFQSLIVKKEFVKENLVKLLNPRY---NLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYL 144

  Fly   134 DMLRKEGDIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARRNDL 198
            |:::|.........||..|::|:.           .|.||.|.:...|..|           :.:
Human   145 DLVKKGVQFPPSEAEAETARQETA-----------QISSNPPTSVPTAPAL-----------SSV 187

  Fly   199 LAQHRLVLCEVQETMQLLNQMLD----------------TYDPANQDVSETLHELYKSCKKHKPI 247
            :|.....:..|.|.:..|:..||                |....|.:..|.|.:|||:.::.:..
Human   188 IAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQER 252

  Fly   248 FQHLPQLLDDSD--AQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTA 310
            ...|..::::.|  .:|:....|.|.|:|. .:|:       ||                     
Human   253 IMDLLVVVENEDVTVELIQVNEDLNNAILG-YERF-------TR--------------------- 288

  Fly   311 SSTTATTSSNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSS------A 369
                     |..::|.:        ..|:...|.|||.|:|      |..||.|:..|      .
Human   289 ---------NQQRILEQ--------NKNQKEATNTTSEPSA------PSQDLLDLSPSPRMPRAT 330

  Fly   370 LAESEAKQQ-------SQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDML 427
            |.|......       |.|..:.|..|:|.:..| ....||.|      :::|...::..| ::.
Human   331 LGELNTMNNQLSGLNFSLPSSDVTNNLKPSLHPQ-MNLLALEN------TEIPPFAQRTSQ-NLT 387

  Fly   428 SEELFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVD 492
            |...:...|   :...|....|  ::|..:|....:...|  |..:|.||               
Human   388 SSHAYDNFL---EHSNSVFLQP--VSLQTIAAAPSNQSLP--PLPSNHPA--------------- 430

  Fly   493 SIDDVPLLSDDVEKKDEAVVAPVTVVPPAKPLSEINVELDNIQATGEQRIVLDDDD 548
                  :...|::..:...|.....:.||.....|..|:|..|..|.|    :|.|
Human   431 ------MTKSDLQPPNYYEVMEFDPLAPAVTTEAIYEEIDAHQHKGAQ----NDGD 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GgaNP_572571.1 VHS_GGA 7..144 CDD:239624 31/139 (22%)
GAT 210..284 CDD:281166 19/91 (21%)
Alpha_adaptinC2 543..644 CDD:197886 2/6 (33%)
TOM1L1NP_005477.2 VHS_Tom1 14..154 CDD:239623 31/138 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..179 8/34 (24%)
GAT_TM1L1 199..290 CDD:260095 21/128 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..327 12/34 (35%)
Interaction with GRB2. /evidence=ECO:0000250 392..395 0/2 (0%)
SH3-binding. /evidence=ECO:0000250 421..425 2/5 (40%)
Interaction with PIK3R1. /evidence=ECO:0000250 442..445 0/2 (0%)
SH2-binding. /evidence=ECO:0000250 460..463 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141223
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D594067at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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