DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gga and gga3b

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_009297383.1	Gene:	gga3b / 100334661	ZFINID:	ZDB-GENE-131126-18	Length:	709	Species:	Danio rerio

Alignment Length:	725	Identity:	183/725 - (25%)
Similarity:	303/725 - (41%)	Gaps:	138/725 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEEMLERATNPAQKIDE----LGVQMFCIVVKSNAQ--------LVHK--AQEMIVAKVRSTNVT 58
            :|..|.:||:|..:.::    :|   ||..:....:        ||||  |||.
Zfish    12 LESWLNKATHPTNRQEDWEYIIG---FCDQINKELEGPQIAVRLLVHKFCAQEW----------- 62

  Fly    59 EATRAISLLEECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEF 123
            ||.:|:::||.||..||..|..|.:::|||||||::||..|.|.....:||.:|:|.|..||..|
Zfish    63 EALQALTVLEACMKNCGRRFHKEIARYRFLNELIKVVSPMYMGNSISEKVKSKIIEMLYSWTVAF 127

  Fly   124 PQRQKIRDAYDMLRKEGDIEHGTTEAAVAK----------RESVLGTIDEA-MFAKLIKSNNPEN 177
            |...||.:||..|:::|.:: ...|..|.|          :..|....|.. :.|:|::|.|||:
Zfish   128 PNEAKIAEAYQTLKRQGLVK-SDPELTVDKTLIPSPPARPKNPVFDNEDMGKLLAELLRSKNPED 191

  Fly   178 FKRANLLLQYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYD-PANQDVS-ETLHELYKS 240
            .:.||.|::..:.::..|...|.:....|.||...::||.:||..|| ..:.|.. |.:.|||:.
Zfish   192 LQEANRLIKNMVKEDDARVHKLTKRINTLEEVNNNVKLLTEMLSQYDRERSSDADRELIKELYER 256

  Fly   241 CKKHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASS 305
            |.|.:.....|....:|:|:.| .|.|.||..|...:..||.:|      ...|....|..:..:
Zfish   257 CDKLRRTAFKLATEAEDNDSSL-GDILKANDDLSRVISCYKRIV------EGQADDGEAEELRPA 314

  Fly   306 VKSTASSTTATTSSNNAQLLNELLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSS-- 368
            ......|.|.|        |.:|.|  |.:.|:..........|..|.:.:..::..:...||
Zfish   315 ANEACESGTGT--------LIDLAG--LDEPSSPPPPPPPAPAPTLAPAPAPQISLATQKASSIP 369

  Fly   369 -------ALAESEAKQQSQP------FQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRK 420
                   .||.:...|.|.|      .|::.:||:.:::|.|...              |.::..
Zfish   370 VLPPPPRRLAGAHGSQTSSPNHKAAEHQSSLSLLDDELLSLGLND--------------PPSVPN 420

  Fly   421 MPQIDMLSE------------ELFQQILPTQDRMPS------------FKRDPEKITLNDLARER 461
            .|::|.||.            :||..|.......||            ..:..:::::.|...|:
Zfish   421 RPKLDDLSAQWTSLQAPDPGLDLFGSISAPSAVFPSTHTPAPTSHTLTHAQGLQELSVLDFGGEK 485

  Fly   462 ----------------MHIKAPEEPTTANDP----ASDSAPAIATATA-TVDSIDDVPLLSDDVE 505
                            ..:.....|.::::|    ....:||::.|.| |..|....|.......
Zfish   486 SVCGASGIAGGAFGQSAAVMCSAAPLSSSNPFVSAPLSGSPAVSRAQAVTGGSAPGSPFFQPFSS 550

  Fly   506 KKDEAVVAPVTVVPPAKPLSEINVELDNIQATGEQRIVL-DDDDMQLSLNFTSDRPGHR--VSVI 567
            .......:|.....|:  |:.::|.|:.|:.:....:.: |.|.:::.|:|..|.|..|  |.|:
Zfish   551 PSHSLQSSPARSSEPS--LTNLHVPLEAIRPSKVLPVTMYDKDGVRVLLHFAMDCPPGRPDVLVM 613

  Fly   568 VISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATPINQVMLLLNPTGKAVDV 632
            |:|..|.:..|||:...:|:|.|..:|:|..|:.:::.|..|..|...|.|||||.||..:.|.:
Zfish   614 VVSLLNTAPLPVRNVVLQAAVPKSMRVKLQPPSGTEICPFNPILPPASITQVMLLANPLKERVRL 678

  Fly   633 TCIVGYKLGD 642
            ...:.|.||:
Zfish   679 RYKLAYLLGE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	52/149 (35%)
		GAT	210..284	CDD:281166	24/75 (32%)
		Alpha_adaptinC2	543..644	CDD:197886	36/103 (35%)
gga3b	XP_009297383.1	VHS_GGA	11..148	CDD:239624	52/150 (35%)
		PARP_reg	<133..207	CDD:280950	19/74 (26%)
		GAT_GGA3	215..301	CDD:260098	28/92 (30%)
		Alpha_adaptinC2	588..701	CDD:197886	36/101 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574138
Domainoid	1	1.000	111	1.000	Domainoid score	I6180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3560
OMA	1	1.010	-	-		QHG51934
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm25303
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.010