DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gga and gga3

DIOPT Version :9

Sequence 1:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_012827013.2	Gene:	gga3 / 100170621	XenbaseID:	XB-GENE-979350	Length:	707	Species:	Xenopus tropicalis

Alignment Length:	746	Identity:	178/746 - (23%)
Similarity:	310/746 - (41%)	Gaps:	165/746 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TDESIMEEMLERATNPAQKIDELG-VQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISL 66
            :|...:|..|.:||||..:.::.. :..||..|....:....|..::..|::|....||.:|:::
Frog     4 SDGETLESWLNKATNPCNRQEDWEYIISFCDQVNKELEGPQIAVRLLAHKIQSPQEWEALQALTV 68

  Fly    67 LEECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLWTTEFPQRQKIRD 131
            ||..|..||..|..|..|||||||||::||.||.|.....:||.:::..|..||...|:..||::
Frog    69 LEASMKNCGRRFHSEVGKFRFLNELIKVVSPKYLGDRISEKVKSKVIGLLYSWTVALPEETKIKE 133

  Fly   132 AYDMLRKEG--------DIEHGTTEAAVAKRESVLGTIDE--AMFAKLIKSNNPENFKRANLLLQ 186
            ||.||:::|        .::|....:...:.::.:...:|  .:.|:|:||.||::.:.||.|::
Frog   134 AYHMLKRQGIILADPEIPVDHTLVPSPPTRPKNPIFDDEERSKILARLLKSKNPDDLQEANKLIK 198

  Fly   187 YRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTY--DPANQDVSETLHELYKSCKKHKPIFQ 249
            ..:.::..|....::....|.||...:.||.:||..|  |.::....|.:.|||:.|:..:....
Frog   199 SMVKEDEVRMQRASKRTHTLEEVSNNVMLLQEMLTHYSKDDSSDGDKELMKELYERCEMKRLALF 263

  Fly   250 HLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTASSTT 314
            .:....:|:|:.| .|.|.|:..|...:..|:..|..
Frog   264 KMASETEDNDSAL-GDILQASDDLSRVINMYRKAVEG---------------------------- 299

  Fly   315 ATTSSNNAQLLNELLGDL-LIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAESEAK-- 376
                       .::.||: |.|..:|...|:...|        :.|.||:|...:.:.:.:.:
Frog   300 -----------QDINGDISLPDTHSKKGDTSHKDL--------STLIDLADSEEAFIPQKDPEPF 345

  Fly   377 -----QQSQPFQNAT--TLLEPQVI----SQG---TTTEALANGNGGSASKVPETIRKMPQIDML 427
                 :|::|.|.:.  .:|.|..:    |:|   .|...|......|.|           :.:|
Frog   346 LPVPTEQAKPEQPSALIPILPPPPLVPTHSRGYYSNTDHFLTQMKSASDS-----------LCLL 399

  Fly   428 SEELFQQILPTQDRMPSFKRDPEKITLNDLAR-ERMHI--------KAPEEPTTAND-------- 475
            .|||..  |...|..||.:.:..:.|:.|:.: |:..:        :.|..||||..
Frog   400 DEELLH--LGLDDPAPSTQSNVSQSTMGDILQVEQSELDFFGPGPDRDPMAPTTAYQMQTMPLQP 462

  Fly   476 --PASDSAPAIATATATVDS---------------IDDVPLLSDDVEKKDEAVVAPVTV------ 517
              |.:.|....|.::|||.|               :..:||.:...:..:.||.:..::
Frog   463 LCPTTISPLYYAHSSATVFSSLPTGPLMVPTAVPPMGRLPLEAIGPQFMEAAVCSSASIQVRPQL 527

  Fly   518 --------------VPPAKP-----------------LSEINVELDNIQATGEQRI-VLDDDDMQ 550
                          |.|..|                 ||.:||.|..|:.:....: ..|.:..:
Frog   528 PMGVMHVSAQFPLPVAPGSPLFLPLQQGSPQKGSDISLSAVNVPLGTIKPSSLLPVTAYDKNGFR 592

  Fly   551 LSLNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPA 613
            :.|:|..:.|..|  |.|:|:|..|.:..||::.|.:|:|.|..||:|..|:.:.:.|..|.:|.
Frog   593 VLLHFAKECPPGRPDVLVVVVSMLNTAPMPVQNIQLQAAVPKTMKVKLQPPSGTDLSPFNPIQPP 657

  Fly   614 TPINQVMLLLNPTGKAVDVTCIVGYKLGDDP 644
            ..|.|||||.||..:.|.:...:.:.||::|
Frog   658 AAITQVMLLANPLKEKVRLRFKLSFVLGEEP 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	49/145 (34%)
		GAT	210..284	CDD:281166	19/75 (25%)
		Alpha_adaptinC2	543..644	CDD:197886	34/102 (33%)
gga3	XP_012827013.2	VHS_GGA3	6..146	CDD:340805	49/139 (35%)
		GGA_N-GAT	169..207	CDD:408115	10/37 (27%)
		GAT_GGA3	213..299	CDD:410587	23/86 (27%)
		Alpha_adaptinC2	585..699	CDD:197886	35/104 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3420
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376337at33208
OrthoFinder	1	1.000	-	-		FOG0001639
OrthoInspector	1	1.000	-	-		otm47966
Panther	1	1.100	-	-	LDO	PTHR45905
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160