DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31904 and SLC6A2

DIOPT Version :9

Sequence 1:	NP_723310.1	Gene:	CG31904 / 319016	FlyBaseID:	FBgn0260479	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001165975.1	Gene:	SLC6A2 / 6530	HGNCID:	11048	Length:	628	Species:	Homo sapiens

Alignment Length:	292	Identity:	64/292 - (21%)
Similarity:	113/292 - (38%)	Gaps:	80/292 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VETESGGG-MGGSLALAARRIRSRQVHSMAVRTGSAYDTLERPYRHD-KCRGRWAKSADFYFASC 98
            |:.|:.|. .|....|.||    :....:.|:..:....|..|...| :.|..|.|..||..:..
Human    10 VQPENNGADTGPEQPLRAR----KTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVV 70

  Fly    99 THA--------FSSLIFSELSTFGILHGGWLLFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTIS 155
            ..|        |..|.:.        :||. .|:|.|.:.::...:|:|.::..|||::..|..:
Human    71 GFAVDLANVWRFPYLCYK--------NGGG-AFLIPYTLFLIIAGMPLFYMELALGQYNREGAAT 126

  Fly   156 AFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSCNNSWNTQECS----- 215
            .:::.|.|||:|||::|:.|....||::.....|.|..:|....:||..|.::||:..|:
Human   127 VWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLL 191

  Fly   216 -----------------------------LHEN---YDVD----------FAVAVIFTLALAMGV 238
                                         |||:   :|:.          ..|.::...:|..||
Human   192 NGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGV 256

  Fly   239 QSS--------VIP--LLSQVAGHGLSYTAVS 260
            ::|        .:|  :|..:..||::....|
Human   257 KTSGKVVWITATLPYFVLFVLLVHGVTLPGAS 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31904	NP_723310.1	SLC5-6-like_sbd	123..>243	CDD:294310	38/174 (22%)
CG31904	NP_723310.1	Cuticle_4	276..344	CDD:292577
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		4/12 (33%)
SLC6A2	NP_001165975.1	SLC6sbd_NET	56..612	CDD:212081	53/242 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810