DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31904 and SLC6A1

DIOPT Version :9

Sequence 1:	NP_723310.1	Gene:	CG31904 / 319016	FlyBaseID:	FBgn0260479	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001335179.1	Gene:	SLC6A1 / 6529	HGNCID:	11042	Length:	599	Species:	Homo sapiens

Alignment Length:	230	Identity:	57/230 - (24%)
Similarity:	96/230 - (41%)	Gaps:	45/230 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ERPYRHDK----------------CRGRWAKSADFYFASCTHAFSSLIFSELSTFGILHG--GWL 121
            |.|..:||                .|..|....||..:...:|..   ...:..|..|.|  |..
Human    19 EAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIG---LGNVWRFPYLCGKNGGG 80

  Fly   122 LFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAV 186
            .|:|.|.:.::|..:|:||::..|||::|.|.:..:::||:|||:|.|..:|:.....||.:...
Human    81 AFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIS 145

  Fly   187 VPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENYDVDFAVAVIFTLALAMGVQSSVIPLLSQVAG 251
            ..:.|..||....:||..|:|.|||..|  ..||          ::.....:.|:|:....:..
Human   146 WAIYYLYNSFTTTLPWKQCDNPWNTDRC--FSNY----------SMVNTTNMTSAVVEFWERNM- 197

  Fly   252 HGLSYTAVSGPAVVASPWAVPAAHWPAAVNVA-SW 285
            |.:: ..:..|..:         .||.|:.:| :|
Human   198 HQMT-DGLDKPGQI---------RWPLAITLAIAW 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31904	NP_723310.1	SLC5-6-like_sbd	123..>243	CDD:294310	36/119 (30%)
CG31904	NP_723310.1	Cuticle_4	276..344	CDD:292577	5/11 (45%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	57/230 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910