DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31904 and Slc6a4

DIOPT Version :9

Sequence 1:	NP_723310.1	Gene:	CG31904 / 319016	FlyBaseID:	FBgn0260479	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_037166.2	Gene:	Slc6a4 / 25553	RGDID:	3714	Length:	630	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	80/334 - (23%)
Similarity:	134/334 - (40%)	Gaps:	97/334 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LNNCMLLGDCENSEHGTELPGDFIGEPVETESGGGMGGSLALAARRIRSRQVHS--MAVRTGSAY 71
            ||:..:|.:|::.|              :.:..|.:...:...|.|....|:.:  .||.:.||.
  Rat     6 LNSQKVLSECKDRE--------------DCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAG 56

  Fly    72 D-----------TLERPYRHDKCRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILH 117
            |           ||....|..: |..|.|..||..:...:|        |..:.:.        :
  Rat    57 DEASHSIPAATTTLVAEIRQGE-RETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQ--------N 112

  Fly   118 GGWLLFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFR-VAPIFKGIGYAILLLNLGTLTYY 181
            ||. .|::.|.:..:|..:|:|.::..|||:..:|.||.:| :.||||||||||.::.....:||
  Rat   113 GGG-AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYY 176

  Fly   182 SIAAVVPLIYTVNSIHPVIPWMSCNNSWNTQECS----------------------------LHE 218
            :......|.|.::|:...:||.||.|||||..|:                            :|:
  Rat   177 NTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQ 241

  Fly   219 ----------NYDVDFAVAVIFTL---ALAMGVQSSVIPLLSQVAGHGLSYTAVSGPAVVASPWA 270
                      ::.:...:.:|||:   ::..||::|         |..:..|| :.|.:|.|...
  Rat   242 SKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTS---------GKVVWVTA-TFPYIVLSVLL 296

  Fly   271 VPAAHWPAA 279
            |..|..|.|
  Rat   297 VRGATLPGA 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31904	NP_723310.1	SLC5-6-like_sbd	123..>243	CDD:294310	44/161 (27%)
CG31904	NP_723310.1	Cuticle_4	276..344	CDD:292577	2/4 (50%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..60		9/36 (25%)
		5HT_transport_N	24..64	CDD:397524	9/39 (23%)
		SLC6sbd_SERT	79..615	CDD:271399	63/246 (26%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910