Protein Alignment HNRNPK and ps

DIOPT Version :10

• Sequence 1: NP_002131.2
• Gene: HNRNPK / 3190
• HGNCID: 5044
• Length: 464
• Species: Homo sapiens
• Sequence 2: NP_001262415.1
• Gene: ps / 44258
• FlyBaseID: FBgn0261552
• Length: 780
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 114/582 - (19%)
• Similarity: 209/582 - (35%)
• Gaps: 191/582 - (32%)

Human    12 NTETNG--EFGKRPAEDMEEEQAFKRSRNT-----DEMVELRILLQSKNAGAVIGKGGKNIKALR 69
            |.:||.  .:|:.....:|.|  .:.:.|.     :....::||:.:..:||:|||||:.|.:|:
  Fly   238 NYKTNSCWCYGESVCSGIEVE--IENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQ 300

Human    70 TDYNASVSVPDS-----SGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDA 129
            .|..|.|.:..|     ...||:..|:...|.|..:::.|:..:.|     .|..|::: :::|:
  Fly   301 KDTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIRE-----KPDLTNKI-VDTDS 359

Human   130 VECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKL--------FQECCP 186
            .:.        .:.|.::::|:..|.||.|||..||.||:::|.:.:.:::        .||.|
  Fly   360 KQT--------QERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERC- 415

Human   187 HSTDRVVLIGGKPDRVVECIKIILDLISESP------------IKGRAQPYDPN---FYDETYDY 236
                 :.:||.|.:....| |:||..|.|.|            :.|....::|.   :.......
  Fly   416 -----ITIIGDKENNKNAC-KMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAI 474

Human   237 GGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGG 301
            ...|...:...|..:|   ........:..|.|           .::|...|.|.|.|
  Fly   475 NSSTASLNSTLGTTIG---GANSAASLLVNGTG-----------INLSINLGSPNPAP------- 518

Human   302 SRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYD-----------------GMVG----------- 338
                ||.:       ...|:.:.:....|..|.                 |::|
  Fly   519 ----NLAV-------ATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGA 572

Human   339 ------FSADETWD--------------------------------SAIDTWSPSEWQM-----A 360
                  |....|.|                                ||.....|::.|:     .
  Fly   573 HSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQ 637

Human   361 YEP----------------QGGSGYDYSYAGGRGSYGDLGG----PI-------ITTQVTIPKDL 398
            ::|                ...:.:..:...|..:...|||    |.       .:..|.:|:.:
  Fly   638 FDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVI 702

Human   399 AGSIIGKGGQRIKQIRHESGASIKIDEP---LEGSEDRIITITGTQDQIQNAQYLLQNSVKQ 457
            .|:|:|..|:.:.:|:|.|||:::|.:.   ..|:.:||:||||....|..||||::..:.:
  Fly   703 IGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINE 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPK	NP_002131.2	Necessary for interaction with DDX1. /evidence=ECO:0000269|PubMed:12183465	1..276		65/298 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		6/26 (23%)
		ROKNT	4..43	CDD:429813	7/37 (19%)
		Interaction with ASFV p30	35..197		43/179 (24%)
		KH-I_HNRNPK_rpt1	42..105	CDD:411860	20/67 (30%)
		2 X 22 AA approximate repeats	54..421		92/492 (19%)
		5 X 4 AA repeats of G-X-G-G	59..407		83/473 (18%)
		KH-I_HNRNPK_rpt2	144..213	CDD:411861	23/76 (30%)
		Interaction with ZIK1. /evidence=ECO:0000250	209..337		23/159 (14%)
		RNA-binding RGG-box	236..273		5/36 (14%)
		2 X 6 AA approximate repeats	245..329		12/83 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..329		11/78 (14%)
		KH-I_HNRNPK_rpt3	387..460	CDD:411862	24/81 (30%)
ps	NP_001262415.1	KH-I_NOVA_rpt1	274..345	CDD:411863	21/70 (30%)
		KH-I_NOVA_rpt2	367..436	CDD:411864	22/75 (29%)
		KH-I_NOVA_rpt3	694..762	CDD:411807	24/67 (36%)