Protein Alignment HNRNPK and HnRNP-K

DIOPT Version :10

• Sequence 1: NP_002131.2
• Gene: HNRNPK / 3190
• HGNCID: 5044
• Length: 464
• Species: Homo sapiens
• Sequence 2: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 187/528 - (35%)
• Similarity: 239/528 - (45%)
• Gaps: 129/528 - (24%)

Human    22 RPAEDMEEE----QAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSS 82
            |...:|.:|    |..||:|..:|.|  |||:.|..|||||||||::|:.:||.|.|:|||.||.
  Fly     6 RMKREMNDEGEGPQDQKRNRRNEETV--RILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQ 68

Human    83 GPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCEL 147
            ||||.:.||||||:..||:                            .|.|.|...:..|||  :
  Fly    69 GPERTIQISADIESTLEII----------------------------TEMLKYFEERDEDFD--V 103

Human   148 RLLIHQSLAGGIIGVKGAKIKELRENTQTT-IKLFQECCPHSTDRVVLIGGKPDRVVECIKIILD 211
            ||||||||||.:||..|.||||:|:..... :|:|....|.||||||...||..:|:|.::.::.
  Fly   104 RLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQSTDRVVQTVGKQSQVIEAVREVIT 168

Human   212 LISESPIKGRAQPYDPNFYDETY--DYGGF---------TMMFDDRRGRPVG------------- 252
            |..::||||....|||..:|..|  :|||:         :...::|.|...|
  Fly   169 LTRDTPIKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAGGNGGG 233

Human   253 -------FPMRGRGGFDRMPPGRGGRPMPP--SRRDYDDMSP-RRGPPPPPPG----RGGRGGSR 303
                   ....||||.||.....||.....  .:||...::| ..|......|    .||.||..
  Fly   234 FNAGGARGNAGGRGGADRFGGAAGGAVAGAGMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFA 298

Human   304 ARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVG----------------FSADETWDSAIDTW 352
            ..:.......|..||........|.|.| :.|..|                ||.::...|::
  Fly   299 GNSFGGGAGGPFGGGSFGNNGFGGGPSD-FGGNSGNFGQAQGTNSLPSLGSFSQNQGGTSSL--- 359

Human   353 SPSEWQMAYEPQGGSGYDYSYAGG-RGSYGDLGG------------------------------- 385
             ||.......|.|..|.....:|| .|..|.|||
  Fly   360 -PSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGANGAGGFNAVGGANGGPNGSPNAATNVPQGH 423

Human   386 -PIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQY 449
             |..:|||||||:|||:||||||.||::||:||.|.|.|||||..|.||||||:||..|||.|||
  Fly   424 DPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITIDEPLPNSNDRIITISGTPKQIQMAQY 488

Human   450 LLQNSVKQ 457
            |||.||.:
  Fly   489 LLQQSVHE 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPK	NP_002131.2	Necessary for interaction with DDX1. /evidence=ECO:0000269|PubMed:12183465	1..276		105/291 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		6/18 (33%)
		ROKNT	4..43	CDD:429813	8/24 (33%)
		Interaction with ASFV p30	35..197		72/162 (44%)
		KH-I_HNRNPK_rpt1	42..105	CDD:411860	36/62 (58%)
		2 X 22 AA approximate repeats	54..421		148/454 (33%)
		5 X 4 AA repeats of G-X-G-G	59..407		134/435 (31%)
		KH-I_HNRNPK_rpt2	144..213	CDD:411861	32/69 (46%)
		Interaction with ZIK1. /evidence=ECO:0000250	209..337		40/165 (24%)
		RNA-binding RGG-box	236..273		14/65 (22%)
		2 X 6 AA approximate repeats	245..329		24/110 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..329		22/105 (21%)
		KH-I_HNRNPK_rpt3	387..460	CDD:411862	49/71 (69%)
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	38/92 (41%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	34/71 (48%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	49/71 (69%)