Protein Alignment Fum4 and FUM1

DIOPT Version :10

• Sequence 1: NP_723527.1
• Gene: Fum4 / 318995
• FlyBaseID: FBgn0051874
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_015061.1
• Gene: FUM1 / 855866
• SGDID: S000006183
• Length: 488
• Species: Saccharomyces cerevisiae
• Alignment Length: 475
• Identity: 243/475 - (51%)
• Similarity: 330/475 - (69%)
• Gaps: 6/475 - (1%)

  Fly    13 YKL-ARLIVPDTRVEYDSMGAVHIPLDRMFGPQTMRSLMKFPIGGVEERMPRPLIKALGIVKKSA 76
            ||| .|.:....|.|.|:.|.:|:|.|:.:|.||.||...|.|||..||||.||:.|.|::||||
Yeast    17 YKLNIRRMNSSFRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSA 81

  Fly    77 AETNK-IHCLEEHLCDAISKACDDVISGKLYDEEHFPLVIWQDGSGEHTNMNVNEVICNRAIEIL 140
            |..|: :..|:..:..||.:|.|:|.||||  ::|||||::|.|||..:|||.||||.|||||||
Yeast    82 AIVNESLGGLDPKISKAIQQAADEVASGKL--DDHFPLVVFQTGSGTQSNMNANEVISNRAIEIL 144

  Fly   141 GGQMGSKEPVDPNEHVNMAQSSHDTFSTAVRIAVAMQLQETLYPSLRTFIDLLGKKSNDWMDLIK 205
            ||::|||: |.||.|.|.:|||:|||.|.:.||.::|:|..|.|.|....:.|..||.::..::|
Yeast   145 GGKIGSKQ-VHPNNHCNQSQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVK 208

  Fly   206 IGRTHLMDAVPLSLGQEFSGYQQQLVNGRTRLDCAMCRLYQLPMGGTSVGTKVDTKAEYSAQCIK 270
            ||||||.||.||:||||||||.||:.||..|:..::..|..|..|||:|||.::||..:..:..:
Yeast   209 IGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVGTGLNTKPGFDVKIAE 273

  Fly   271 RIAELTFLPFVESPNFFESISACDCLVELHGELNTIAASVMKIANDIRFLGSGPRCGFGELHLPE 335
            :|::.|.|.|..:||.||:::|.|.:||..|.|||:|.|:.|||.|||:||||||||:.||.|||
Yeast   274 QISKETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLPE 338

  Fly   336 NEPGSSIMPGKVNPTQCEAMSMICAQVMGNHVAVSMGGSSGHFQLNTFMPMIASNVLRSITLLGD 400
            ||||||||||||||||.||::.:|.|||||:.|::..||.|.|:||.|.|::.:|:|.||.|:.|
Yeast   339 NEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLNSIRLITD 403

  Fly   401 GMKSFCTNCLEGIEPNRSKIGSIVKESLMLVTALSPHIGYERSAAIAKAAHHNGTTLEQEAILDG 465
            ...||..:|:|||:.|..:|..::.:||||||||:|.|||:.::.:||.||..|.||::.|:..|
Yeast   404 AAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKKGITLKESALELG 468

  Fly   466 IQRE-DFREWVQPSKMLGPE 484
            :..| :|.|||.|..||||:
Yeast   469 VLTEKEFDEWVVPEHMLGPK 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fum4	NP_723527.1	Fumarase_classII	24..480	CDD:176465	235/457 (51%)
FUM1	NP_015061.1	FumC	26..486	CDD:439884	236/462 (51%)