DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fum4 and fh

DIOPT Version :9

Sequence 1:NP_723527.1 Gene:Fum4 / 318995 FlyBaseID:FBgn0051874 Length:484 Species:Drosophila melanogaster
Sequence 2:NP_957257.1 Gene:fh / 393938 ZFINID:ZDB-GENE-010724-6 Length:509 Species:Danio rerio


Alignment Length:462 Identity:271/462 - (58%)
Similarity:348/462 - (75%) Gaps:3/462 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 RVEYDSMGAVHIPLDRMFGPQTMRSLMKFPIGGVEERMPRPLIKALGIVKKSAAETNKIHCLEEH 88
            |:|.|:.|.:.:|.|:.:|.||:||.|.|.||||.||||..:|:|.||:||:|||.||.:.|:..
Zfish    50 RIERDTFGELKVPSDKYYGAQTVRSTMNFRIGGVTERMPIQVIRAFGILKKAAAEVNKDYGLDPK 114

  Fly    89 LCDAISKACDDVISGKLYDEEHFPLVIWQDGSGEHTNMNVNEVICNRAIEILGGQMGSKEPVDPN 153
            :.|||.||.|:|.||||  ::|||||:||.|||..|||||||||.|||||:|||::|||:||.||
Zfish   115 IADAIMKAADEVESGKL--DDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGKLGSKDPVHPN 177

  Fly   154 EHVNMAQSSHDTFSTAVRIAVAMQLQETLYPSLRTFIDLLGKKSNDWMDLIKIGRTHLMDAVPLS 218
            :|||.:|||:|||.||:.||.|.::.|.|.|.|:|..|.|..|:..:.|:|||||||..||||||
Zfish   178 DHVNKSQSSNDTFPTAMHIAAAKEVHEVLLPGLQTLHDALAAKAEQFKDIIKIGRTHTQDAVPLS 242

  Fly   219 LGQEFSGYQQQLVNGRTRLDCAMCRLYQLPMGGTSVGTKVDTKAEYSAQCIKRIAELTFLPFVES 283
            |||||.||.||:.....|:..::.|:|:|..|||:|||.::|:..::.:...:::.||.||||.:
Zfish   243 LGQEFGGYVQQVKYSIARVKASLPRVYELAAGGTAVGTGLNTRIGFAEKVADKVSALTGLPFVTA 307

  Fly   284 PNFFESISACDCLVELHGELNTIAASVMKIANDIRFLGSGPRCGFGELHLPENEPGSSIMPGKVN 348
            .|.||:::|.|.||||.|.|||:|.|:|||||||||||||||.|.|||.||||||||||||||||
Zfish   308 ANKFEALAAHDALVELSGALNTVAVSMMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVN 372

  Fly   349 PTQCEAMSMICAQVMGNHVAVSMGGSSGHFQLNTFMPMIASNVLRSITLLGDGMKSFCTNCLEGI 413
            |||||||:|:.||||||||||::|||:|||:||.|.|||..|||.|..||||...||..||:.||
Zfish   373 PTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMIIKNVLNSARLLGDASVSFTNNCVVGI 437

  Fly   414 EPNRSKIGSIVKESLMLVTALSPHIGYERSAAIAKAAHHNGTTLEQEAI-LDGIQREDFREWVQP 477
            |.|..:|..::.|||||||||:|||||:::|.|||.||.:|:||::.|: |..:..:.|.|||:|
Zfish   438 EANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKDGSTLKEAALKLGFLNEQQFEEWVRP 502

  Fly   478 SKMLGPE 484
            ..||||:
Zfish   503 HDMLGPK 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fum4NP_723527.1 fumC 22..483 CDD:234779 269/459 (59%)
Fumarase_classII 24..480 CDD:176465 267/456 (59%)
fhNP_957257.1 fumC 46..509 CDD:234779 270/460 (59%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 144..146 1/1 (100%)
Substrate binding (B site). /evidence=ECO:0000250|UniProtKB:P05042 175..178 1/2 (50%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 185..187 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P9WN93 370..372 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596188
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG61095
OrthoDB 1 1.010 - - D1022919at2759
OrthoFinder 1 1.000 - - FOG0002459
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101016
Panther 1 1.100 - - O PTHR11444
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1641
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
109.720

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