DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum4 and Fum2

DIOPT Version :9

Sequence 1:	NP_723527.1	Gene:	Fum4 / 318995	FlyBaseID:	FBgn0051874	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_727109.2	Gene:	Fum2 / 31606	FlyBaseID:	FBgn0029890	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	283/461 - (61%)
Similarity:	366/461 - (79%)	Gaps:	0/461 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RVEYDSMGAVHIPLDRMFGPQTMRSLMKFPIGGVEERMPRPLIKALGIVKKSAAETNKIHCLEEH 88
            |.|.|:.|.:.:|.|:::|.|||||.:.||||.:.||||.|:|:|:||:||:.||.||.:.|:..
  Fly    43 RTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYGLDGK 107

  Fly    89 LCDAISKACDDVISGKLYDEEHFPLVIWQDGSGEHTNMNVNEVICNRAIEILGGQMGSKEPVDPN 153
            :.||:|.|||||||||||.:.||||||||.|||..||||.||||.|.||:::||::|||:||.||
  Fly   108 VSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVHPN 172

  Fly   154 EHVNMAQSSHDTFSTAVRIAVAMQLQETLYPSLRTFIDLLGKKSNDWMDLIKIGRTHLMDAVPLS 218
            :|||.:|||:|||.||:.|:|.|:|.|.|.|::....|.|..||:::.|:||||||||||||||:
  Fly   173 DHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVPLT 237

  Fly   219 LGQEFSGYQQQLVNGRTRLDCAMCRLYQLPMGGTSVGTKVDTKAEYSAQCIKRIAELTFLPFVES 283
            ||||||||.|||.||..|:...:.|:|:|.:|||:|||.::|:..::.:..|||:|||.||||.:
  Fly   238 LGQEFSGYTQQLTNGLERIKGCLPRVYELALGGTAVGTGLNTRKGFAEKVAKRISELTCLPFVSA 302

  Fly   284 PNFFESISACDCLVELHGELNTIAASVMKIANDIRFLGSGPRCGFGELHLPENEPGSSIMPGKVN 348
            ||.||:::|.|.:||:||.|||||.|:||||||||.||||||||.|||.||||||||||||||||
  Fly   303 PNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKVN 367

  Fly   349 PTQCEAMSMICAQVMGNHVAVSMGGSSGHFQLNTFMPMIASNVLRSITLLGDGMKSFCTNCLEGI 413
            |||||:|:|:|||||||.|||::|||:|||:||.|.|::.|||||||.||.||..:|..||:||:
  Fly   368 PTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVEGL 432

  Fly   414 EPNRSKIGSIVKESLMLVTALSPHIGYERSAAIAKAAHHNGTTLEQEAILDGIQREDFREWVQPS 478
            :.|:.:|..|:.|||||||||:|||||:::|.|||.||.|.|||::||:..||..|.|:|||.|.
  Fly   433 QANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLKEEALKTGITEEQFKEWVNPK 497

  Fly   479 KMLGPE 484
            :||||:
  Fly   498 EMLGPK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum4	NP_723527.1	fumC	22..483	CDD:234779	281/458 (61%)
Fum4	NP_723527.1	Fumarase_classII	24..480	CDD:176465	279/455 (61%)
Fum2	NP_727109.2	fumC	42..503	CDD:234779	282/459 (61%)
Fum2	NP_727109.2	Fumarase_classII	43..499	CDD:176465	279/455 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471477
Domainoid	1	1.000	390	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E1_COG0114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I15
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm51349
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	P	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
	11	10.800