DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fum4 and Fh

DIOPT Version :9

Sequence 1:NP_723527.1 Gene:Fum4 / 318995 FlyBaseID:FBgn0051874 Length:484 Species:Drosophila melanogaster
Sequence 2:NP_058701.2 Gene:Fh / 24368 RGDID:2614 Length:507 Species:Rattus norvegicus


Alignment Length:462 Identity:272/462 - (58%)
Similarity:347/462 - (75%) Gaps:3/462 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 RVEYDSMGAVHIPLDRMFGPQTMRSLMKFPIGGVEERMPRPLIKALGIVKKSAAETNKIHCLEEH 88
            |:|||:.|.:.:|.|:.:|.||:||.|.|.|||..||||.|:|||.||:|::|||.|:.:.|:..
  Rat    48 RIEYDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIKAFGILKRAAAEVNQEYGLDPK 112

  Fly    89 LCDAISKACDDVISGKLYDEEHFPLVIWQDGSGEHTNMNVNEVICNRAIEILGGQMGSKEPVDPN 153
            :..||.||.|:|..|||.|  |||||:||.|||..|||||||||.|||||:|||::|||:||.||
  Rat   113 IASAIMKAADEVAEGKLND--HFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPN 175

  Fly   154 EHVNMAQSSHDTFSTAVRIAVAMQLQETLYPSLRTFIDLLGKKSNDWMDLIKIGRTHLMDAVPLS 218
            :|||.:|||:|||.||:.||.|:::.:.|.|.|:...|.|..||.::..:|||||||..|||||:
  Rat   176 DHVNKSQSSNDTFPTAMHIAAALEVHQVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLT 240

  Fly   219 LGQEFSGYQQQLVNGRTRLDCAMCRLYQLPMGGTSVGTKVDTKAEYSAQCIKRIAELTFLPFVES 283
            ||||||||.||:.....|:..||.|:|:|..|||:|||.::|:..::.:...::|.||.||||.:
  Rat   241 LGQEFSGYVQQVQYAMERIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTA 305

  Fly   284 PNFFESISACDCLVELHGELNTIAASVMKIANDIRFLGSGPRCGFGELHLPENEPGSSIMPGKVN 348
            ||.||:::|.|.||||.|.:||.|.|:|||||||||||||||.|.|||.||||||||||||||||
  Rat   306 PNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVN 370

  Fly   349 PTQCEAMSMICAQVMGNHVAVSMGGSSGHFQLNTFMPMIASNVLRSITLLGDGMKSFCTNCLEGI 413
            |||||||:|:.||||||||||::|||:|||:||.|.||:..|||.|..||||...||..||:.||
  Rat   371 PTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGI 435

  Fly   414 EPNRSKIGSIVKESLMLVTALSPHIGYERSAAIAKAAHHNGTTLEQEAI-LDGIQREDFREWVQP 477
            :.|..:|..::.|||||||||:|||||:::|.|||.||.||:||::.|| |..:..|.|.|||:|
  Rat   436 QANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKP 500

  Fly   478 SKMLGPE 484
            ..||||:
  Rat   501 KDMLGPK 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fum4NP_723527.1 fumC 22..483 CDD:234779 270/459 (59%)
Fumarase_classII 24..480 CDD:176465 268/456 (59%)
FhNP_058701.2 fumC 46..507 CDD:234779 271/460 (59%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 142..144 1/1 (100%)
Substrate binding (B site). /evidence=ECO:0000250|UniProtKB:P05042 173..176 1/2 (50%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P05042 183..185 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P9WN93 368..370 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353979
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG61095
OrthoDB 1 1.010 - - D1022919at2759
OrthoFinder 1 1.000 - - FOG0002459
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101016
Panther 1 1.100 - - O PTHR11444
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1641
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.720

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