DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ada1-2 and TADA1

DIOPT Version :9

Sequence 1:	NP_723703.1	Gene:	Ada1-2 / 318992	FlyBaseID:	FBgn0051866	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_444281.1	Gene:	TADA1 / 117143	HGNCID:	30631	Length:	335	Species:	Homo sapiens

Alignment Length:	327	Identity:	98/327 - (29%)
Similarity:	152/327 - (46%)	Gaps:	63/327 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKI---- 68
            |.|:.|..|||||.::|.||:|.||:.:.:|||||.|:.::||.|.:|.||.||||:|.:.
Human    10 AAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILV 74

  Fly    69 ---DAFAPLENPPAVQTSSSSGNRSKRRKRSS--RTFAERLNFE--LSDVLDFVAEDNMQIIRPP 126
               |....|..|..  :::..|....::|.||  :.|..|...:  ||....|||:|
Human    75 STPDGAGSLPWPGG--SAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKD-------- 129

  Fly   127 TTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLK 191
                 |.|....:|     |:..:.||..|.:.||.::.|:|.||.:|.:.....|..||:..||
Human   130 -----PQDDDDLKL-----CSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLK 184

  Fly   192 DLLSAIIKKRKHYKTSGEGNFYYDVGAPLR-DPSLRNTVTR-----------------QKVDDTP 238
            |:|::::.:||.|:.. :|:|.|..|:.:. .|.|:|:|..                 |.....|
Human   185 DILTSVVSRRKAYRLR-DGHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFTAPCAGQNPASHP 248

  Fly   239 LELDKELNTANFMRRQNDDVTFLSACE-EVQPTERTVITLKDCQLALR-DRNLIGSHAVYSINME 301
            ...|.|...|           .|.||. :..|.....:.:.|...||: .|.:|.:|.||::|:|
Human   249 PPDDAEQQAA-----------LLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIE 302

  Fly   302 RL 303
            |:
Human   303 RI 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada1-2	NP_723703.1	SAGA-Tad1	10..>74	CDD:289533	31/70 (44%)
TADA1	NP_444281.1	SAGA-Tad1	7..193	CDD:403847	67/202 (33%)
TADA1	NP_444281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..103		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28J95
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41793
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4786
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48593
OrthoDB	1	1.010	-	-		D1528613at2759
OrthoFinder	1	1.000	-	-		FOG0006090
OrthoInspector	1	1.000	-	-		otm40825
orthoMCL	1	0.900	-	-		OOG6_108336
Panther	1	1.100	-	-	LDO	PTHR21277
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5181
SonicParanoid	1	1.000	-	-		X4384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800