DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LPCAT and Agpat2

DIOPT Version :9

Sequence 1:	NP_001036265.1	Gene:	LPCAT / 31899	FlyBaseID:	FBgn0052699	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_080488.1	Gene:	Agpat2 / 67512	MGIID:	1914762	Length:	278	Species:	Mus musculus

Alignment Length:	243	Identity:	56/243 - (23%)
Similarity:	98/243 - (40%)	Gaps:	63/243 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LTVLLLPIRV---------VG--CV--LSLISAWMFACIGLY-GMTLDDLKAKPLTGWRKQMQYM 121
            |.:|||.:::         ||  ||  ||..:|....|:..: |.|:|::.   :..|..:
Mouse    11 LLLLLLLVQLSRTARFYAKVGLYCVLCLSFSAAASIVCLLRHGGRTVDNMS---IISWFVR---- 68

  Fly   122 TACGMRMVYTFGSFHYV-----TMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIV--AKR 179
                        ||.||     .:.|:.....:.|.::::.|.|.:|.:.::...|...|  |||
Mouse    69 ------------SFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKR 121

  Fly   180 ETADIPLLGKIINYAQPIYVQREDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALIKF 244
            |......:|.|:......::.|:...:..:.:.|:.|  ....:..:|.|:.|||..:...|:.|
Mouse   122 ELMFTGPVGLIMYLGGVYFINRQQARTAMSVMADLGD--LMVKENLKVWIYPEGTRNDNGDLLPF 184

  Fly   245 KPGAFYPGVPVQ-PVLLKYPNKYDTFTWTWDGPGVLRLLWLTMTQFYN 291
            |.||||..:..| |::   |..|.:|                 :.|||
Mouse   185 KKGAFYLAIQAQVPII---PVVYSSF-----------------SSFYN 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	PlsC	87..>265	CDD:223282	41/186 (22%)
		LPLAT_LPCAT1-like	126..338	CDD:153253	40/174 (23%)
		EF-hand_8	455..507	CDD:290545
Agpat2	NP_080488.1	PlsC	30..259	CDD:223282	52/224 (23%)
		LPLAT_AGPAT-like	67..240	CDD:153251	40/184 (22%)
		HXXXXD motif. /evidence=ECO:0000250\|UniProtKB:Q9D517	98..103		2/4 (50%)
		EGTR motif. /evidence=ECO:0000250\|UniProtKB:O15120	172..175		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810